INT207805

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.18
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.98
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53)
enzyme binding (Trp53) protein complex assembly (Trp53) DNA binding (Trp53)
Anatomy Link Frequency
null cells 2
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 70 90.48 High High
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 1 96.76 Very High Very High Very High
Death 2 94.20 High High
Cancer 25 88.24 High High
Breast Cancer 1 87.60 High High
Carcinoma 18 79.08 Quite High
Apoptosis 7 75.36 Quite High
Gallbladder Neoplasms 47 67.76 Quite High
Disease 3 54.44 Quite High
Skin Cancer 2 43.44 Quite Low
Telangiectasia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, environmental factors that cause DNA damage lead to the phosphorylation of p53 which prevents a pathway required for the transcription of S-phase genes, thereby maintaining G1/S phase arrest [18].
Negative_regulation (prevents) of Phosphorylation (phosphorylation) of p53
1) Confidence 0.18 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1931603 Disease Relevance 0.98 Pain Relevance 0.15
Previous results from our group have shown that PARP-1 null cells have a deficient p53 ser15 phosphorylation in response to ionising radiation [15], confirming with a different ATM substrate that ATM activation is compromised in the absence of PARP-1.
Negative_regulation (deficient) of Phosphorylation (phosphorylation) of p53 in null cells
2) Confidence 0.10 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox