INT207806

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Context Info
Confidence 0.81
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.07
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Atm) cell cycle (Atm) DNA binding (Atm)
kinase activity (Atm) cytoplasm (Atm)
Atm (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 7 58.56 Quite High
cerebral cortex 14 5.00 Very Low Very Low Very Low
fibrosis 14 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 20 100.00 Very High Very High Very High
Ataxia 8 99.80 Very High Very High Very High
Disease 123 95.76 Very High Very High Very High
Apoptosis 23 94.56 High High
Breast Cancer 245 92.00 High High
Embryonic Lethality 2 91.88 High High
Genomic Instability 5 90.56 High High
Targeted Disruption 75 85.20 High High
Metastasis 11 85.00 Quite High
Repression 5 84.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following DNA damage, each ATM molecule phosphorylates the other on a serine residue at position 1981 within the FAT domain, a phosphorylation that releases the two molecules from each other's grip, turning them into fully active monomers.
Phosphorylation (phosphorylates) of ATM molecule
1) Confidence 0.81 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.18 Pain Relevance 0.06
It has been shown that IR induces the instantaneous phosphorylation of the ATM protein at Ser-1981 leading to catalytic activation by dimer dissociation rendering the kinase domain accessible [22].
Phosphorylation (phosphorylation) of ATM
2) Confidence 0.75 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1971057 Disease Relevance 0 Pain Relevance 0
ATM possesses kinase activity and phosphorylates serine and threonine amino acids in several important downstream cell cycle proteins such as p53, BRCA1/2, CHK1/2 and c-Abl [18,20,21].
Phosphorylation (phosphorylates) of ATM
3) Confidence 0.58 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1971057 Disease Relevance 0.05 Pain Relevance 0
Furthermore, a recent study has shown that in vitro, PARP-1 inhibited the activation a subset of ATM substrates such as phosphorylation of p53 on serine 15 [13].
Phosphorylation (phosphorylation) of ATM
4) Confidence 0.54 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.15 Pain Relevance 0
Insufficient function of Ku70 might also enhance ATM-mediated signaling, as persistent phosphorylation of p53 at Ser18 by the ATM activity was observed in irradiated Ku70-deficient cells in contrast to transient activation of p53 in control cells (Tomimatsu et al., 2007).
Phosphorylation (phosphorylation) of ATM
5) Confidence 0.45 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.55 Pain Relevance 0
However, other kinases, such as ataxia telangiectasia mutated (ATM), a mediator of DNA damageĀ–induced cell death signaling (Lombard et al., 2005; for review see Sancar et al., 2004), are also known to phosphorylate H2AX (Fernandez-Capetillo et al., 2004; Lu et al., 2006), and activation of ATM has been observed in the HD pathology (Qi et al., 2007).
Phosphorylation (phosphorylate) of ATM associated with ataxia, disease and death
6) Confidence 0.39 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.65 Pain Relevance 0
BRCA1 and BRCA2 proteins are also found in complexes with Rad51, a protein important for the cellular response to DNA damage.192,194 In addition, BRCA1 is phosphorylated by the ATM/ATR kinases, in response to DNA damage (Fig. 1).
Phosphorylation (phosphorylated) of ATM
7) Confidence 0.31 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.90 Pain Relevance 0
Furthermore, these authors showed that microcephalin/BRIT1 co-localizes to DNA damage response proteins, such as MDC1, 53BP1, NBS1, and phosphorylated ATM and is required for the activation of these proteins.
Phosphorylation (phosphorylated) of ATM
8) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0.59 Pain Relevance 0

General Comments

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