INT207807

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Context Info
Confidence 0.74
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 0.21
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Atm) cell cycle (Atm) DNA binding (Atm)
kinase activity (Atm) cytoplasm (Atm)
Anatomy Link Frequency
poly 2
body 1
Atm (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 8 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Genomic Instability 3 91.88 High High
Apoptosis 9 62.44 Quite High
Targeted Disruption 3 56.88 Quite High
Skin Cancer 6 40.72 Quite Low
Telangiectasia 15 5.00 Very Low Very Low Very Low
Body Weight 12 5.00 Very Low Very Low Very Low
Cancer 12 5.00 Very Low Very Low Very Low
Ataxia 9 5.00 Very Low Very Low Very Low
Decapitation 8 5.00 Very Low Very Low Very Low
Endocrine Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data presented in this study strongly support a role for PARP-1 and poly (ADP-ribose) in ATM activation: in the absence of PARP-1 there is a deficient ATM-kinase activation in response to ionizing radiation as measured by intrinsic kinase activity and H2AX phosphorylation.
Neg (absence) Localization (absence) of ATM in poly
1) Confidence 0.74 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.21 Pain Relevance 0
Again, confocal microscopy confirmed the co-localisation of ATM and poly (ADP) ribose after ionizing radiation (figure 2B).
Localization (localisation) of ATM in poly
2) Confidence 0.74 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0 Pain Relevance 0
Both ATM and PARP-1 are localised in foci after DNA damage.
Localization (localised) of ATM
3) Confidence 0.74 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0 Pain Relevance 0
In Fig. 6 the cumulative in vitro release of hGH (ATM1, ATM2) and the cumulative administered amount of hGH (control) are plotted against the observed pharmacodynamic effect (increase in body length).
Localization (release) of ATM2 in body
4) Confidence 0.03 Published 2007 Journal Pharm Res Section Body Doc Link PMC2063566 Disease Relevance 0 Pain Relevance 0
Furthermore, Fig. 6b shows that hGH released from dex-HEMA microspheres is as effective as hGH administered via daily injections as there is no difference between growth response to a certain amount hGH administered by single daily injection of a solution of hGH and to the same amount of hGH released from either small microspheres (ATM2) or large microspheres (ATM1).
Localization (released) of ATM2
5) Confidence 0.03 Published 2007 Journal Pharm Res Section Body Doc Link PMC2063566 Disease Relevance 0 Pain Relevance 0
In Fig. 3, the cumulative release profiles of hGH from the ATM1 and ATM2 batches are shown.
Localization (release) of ATM2
6) Confidence 0.02 Published 2007 Journal Pharm Res Section Body Doc Link PMC2063566 Disease Relevance 0 Pain Relevance 0
The ED50 for the binding of 125I-hGH to antibodies in the serum was obtained at serum dilutions of approximately 200×, 800× and 1,200× for free hGH, hGH released from microspheres from ATM1 and ATM2 respectively.
Localization (released) of ATM2
7) Confidence 0.01 Published 2007 Journal Pharm Res Section Body Doc Link PMC2063566 Disease Relevance 0 Pain Relevance 0

General Comments

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