INT207812

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 12
Disease Relevance 0.99
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Parp1, Atm) nucleoplasm (Parp1) nuclear envelope (Parp1)
DNA binding (Atm) protein complex (Parp1) cytoplasm (Atm)
Anatomy Link Frequency
poly 5
Parp1 (Mus musculus)
Atm (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 12 9.16 Low Low
Disease Link Frequency Relevance Heat
Cancer 48 95.36 Very High Very High Very High
Embryonic Lethality 12 87.36 High High
Aging 12 81.32 Quite High
Skin Cancer 24 77.84 Quite High
Telangiectasia 60 44.40 Quite Low
Targeted Disruption 12 18.36 Low Low
Lymphatic System Cancer 12 12.08 Low Low
Female Infertility 12 10.32 Low Low
Apoptosis 36 5.00 Very Low Very Low Very Low
Ataxia 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, these results are the first indication that ATM is physically associated to PARP-1 and is a substrate for this enzyme, co-localizing in the same foci after DNA damage.


PARP-1 Binding (associated) of ATM
1) Confidence 0.54 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.05 Pain Relevance 0
One key question derived from the previous results concern the functional consequences of the interaction between PARP-1 and ATM and between poly (ADP-ribosyl)ation and ATM on ATM activation.
PARP-1 Binding (interaction) of ATM in poly
2) Confidence 0.40 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.08 Pain Relevance 0
In this regard, a link between ATM and PARP-1 is supported by recent findings.
PARP-1 Binding (link) of ATM
3) Confidence 0.40 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.16 Pain Relevance 0
PARP-1 and ATM recognize and bound to both single and double strand DNA breaks in response to different triggers.
PARP-1 Binding (bound) of ATM
4) Confidence 0.40 Published 2007 Journal BMC Mol Biol Section Abstract Doc Link PMC1868035 Disease Relevance 0 Pain Relevance 0
The aim of this study has been to elucidate the interaction between PARP-1 and ATM and how this partnership is involved in regulation of DNA repair pathways.
PARP-1 Binding (interaction) of ATM
5) Confidence 0.40 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.14 Pain Relevance 0
We present evidences showing a physical association between ATM and PARP-1 in response to DNA damage as well as a poly (ADP-ribosyl)ation of ATM.
PARP-1 Binding (association) of ATM in poly
6) Confidence 0.40 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.08 Pain Relevance 0
One key question derived from the previous results concern the functional consequences of the interaction between PARP-1 and ATM and between poly (ADP-ribosyl)ation and ATM on ATM activation.
PARP-1 Binding (interaction) of ATM in poly
7) Confidence 0.40 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.07 Pain Relevance 0
PARP-1 interacts with ATM in vivo and ATM is modified by poly(ADP-ribosyl)ation
PARP-1 Binding (interacts) of ATM in poly
8) Confidence 0.40 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.06 Pain Relevance 0
In this study we demonstrate the physical interaction between PARP-1 and ATM in response to ionizing radiation, the modification of ATM by poly(ADP-ribose) and the functional consequences of this interaction in PARP-1 deficient cells, where the activation of ATM kinase is compromised in response to IR.
PARP-1 Binding (interaction) of ATM in poly
9) Confidence 0.40 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.08 Pain Relevance 0
PARP-1 and ATM recognize and bound to both single and double strand DNA breaks in response to different triggers.
PARP-1 Binding (recognize) of ATM
10) Confidence 0.40 Published 2007 Journal BMC Mol Biol Section Abstract Doc Link PMC1868035 Disease Relevance 0 Pain Relevance 0
In summary, our study demonstrates a strong association between ATM and PARP-1 during the response to ionizing radiation, being PARP-1 and its activity needed for optimal activation of ATM kinase.
PARP-1 Binding (association) of ATM
11) Confidence 0.40 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.27 Pain Relevance 0
Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition

ATM and PARP-1 are two of the most important players in the cell's response to DNA damage.

PARP-1 Binding (Interaction) of ATM
12) Confidence 0.40 Published 2007 Journal BMC Mol Biol Section Title Doc Link PMC1868035 Disease Relevance 0 Pain Relevance 0

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