INT207813

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2007
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Atm, Parp1) nucleoplasm (Parp1) nuclear envelope (Parp1)
DNA binding (Atm) protein complex (Parp1) cytoplasm (Atm)
Anatomy Link Frequency
poly 2
Atm (Mus musculus)
Parp1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 4 87.56 High High
Targeted Disruption 1 43.00 Quite Low
Genomic Instability 1 11.32 Low Low
Telangiectasia 5 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Ataxia 3 5.00 Very Low Very Low Very Low
Skin Cancer 2 5.00 Very Low Very Low Very Low
Female Infertility 1 5.00 Very Low Very Low Very Low
Embryonic Lethality 1 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From the results presented here, there is a clear duality in the effect of PARP inhibition on ATM: while the lack of response to IR in ANI treated cells indicates that poly (ADP-rybosylation) of ATM is probably needed for optimal ATM activation, long term exposure to PARP inhibitor results in the generation of DSBs and secondarily in the activation of ATM kinase.
ATM Spec (clear) Regulation (effect) of Neg (inhibition) Gene_expression (inhibition) of PARP in poly
1) Confidence 0.44 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.31 Pain Relevance 0

General Comments

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