INT207816

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Context Info
Confidence 0.51
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.21
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Parp1, Atm) nucleoplasm (Parp1) nuclear envelope (Parp1)
DNA binding (Atm) protein complex (Parp1) cytoplasm (Atm)
Anatomy Link Frequency
poly 2
Parp1 (Mus musculus)
Atm (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Genomic Instability 1 94.44 High High
Apoptosis 3 65.00 Quite High
Targeted Disruption 1 52.80 Quite High
Telangiectasia 5 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Ataxia 3 5.00 Very Low Very Low Very Low
Skin Cancer 2 5.00 Very Low Very Low Very Low
Female Infertility 1 5.00 Very Low Very Low Very Low
Embryonic Lethality 1 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data presented in this study strongly support a role for PARP-1 and poly (ADP-ribose) in ATM activation: in the absence of PARP-1 there is a deficient ATM-kinase activation in response to ionizing radiation as measured by intrinsic kinase activity and H2AX phosphorylation.
PARP-1 Regulation (role) of Positive_regulation (activation) of ATM in poly
1) Confidence 0.51 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.21 Pain Relevance 0

General Comments

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