INT207817

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Context Info
Confidence 0.53
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.20
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Parp1, Atm) nucleoplasm (Parp1) nuclear envelope (Parp1)
DNA binding (Atm) protein complex (Parp1) cytoplasm (Atm)
Parp1 (Mus musculus)
Atm (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 8 88.48 High High
Telangiectasia 10 28.72 Quite Low
Skin Cancer 4 26.96 Quite Low
Targeted Disruption 2 11.48 Low Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Ataxia 6 5.00 Very Low Very Low Very Low
Female Infertility 2 5.00 Very Low Very Low Very Low
Embryonic Lethality 2 5.00 Very Low Very Low Very Low
Genomic Instability 2 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary our results show that while PARP-1 is needed in the response of ATM to gamma irradiation, the inhibition of PARP induces DNA double strand breaks (which are resolved in and ATM-dependent pathway) and activates ATM kinase.



Negative_regulation (inhibition) of PARP Positive_regulation (activates) of ATM kinase
1) Confidence 0.53 Published 2007 Journal BMC Mol Biol Section Abstract Doc Link PMC1868035 Disease Relevance 0 Pain Relevance 0
On the other hand, inhibition of PARP leads to the activation of ATM kinase as result of the generation of DSBs, making ATM deficient cells particularly sensitive to PARP inhibitors.


Negative_regulation (inhibition) of PARP Positive_regulation (activation) of ATM kinase
2) Confidence 0.53 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.20 Pain Relevance 0

General Comments

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