INT207818

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.67
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnj11) mitochondrion (Kcnj11) endoplasmic reticulum (Kcnj11)
plasma membrane (Kcnj11) neurological system process (Kcnj11)
Anatomy Link Frequency
pore 1
Kcnj11 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 11 75.64 Quite High
antagonist 8 66.80 Quite High
conotoxin 12 5.00 Very Low Very Low Very Low
tetrodotoxin 10 5.00 Very Low Very Low Very Low
Action potential 8 5.00 Very Low Very Low Very Low
gABA 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 130 100.00 Very High Very High Very High
Disease 6 92.56 High High
Genetic Predisposition To Disease 3 91.60 High High
Impaired Glucose Tolerance 11 75.64 Quite High
Obesity 6 56.08 Quite High
Hyperinsulinism 1 26.16 Quite Low
Metabolic Syndrome 9 5.00 Very Low Very Low Very Low
Myocardial Infarction 6 5.00 Very Low Very Low Very Low
Hypoglycemia 5 5.00 Very Low Very Low Very Low
Insulin Resistance 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cohort 1, we genotyped all 25 SNPs (n = 661) and found that Ser1369Ala of the ABCC8 gene and rs5210 of the KCNJ11 gene were significantly associated with decreases in FPG (P = 0.002).
Positive_regulation (rs5210) of KCNJ11
1) Confidence 0.48 Published 2008 Journal Diabetes Care Section Abstract Doc Link PMC2551631 Disease Relevance 0.35 Pain Relevance 0.04
Future studies should screen for mutations within both the SUR1 gene and nearby genes, such as KCNJ11.
Positive_regulation (screen) of KCNJ11
2) Confidence 0.48 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2551631 Disease Relevance 0.35 Pain Relevance 0
Five genome-wide association studies have been published since February 2007, increasing the number of confirmed type 2 diabetes susceptibility loci from three (PPARG, KCNJ11, and TCF7L2) to 9 (with the addition of CDKAL1, CDKN2A/B, IGF2BP2, HHEX/IDE, FTO, and SLC30A8) (2).
Positive_regulation (increasing) of KCNJ11 associated with diabetes mellitus
3) Confidence 0.45 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2551631 Disease Relevance 0.98 Pain Relevance 0
-cell KATP channels as regulators of glucagon secretion, we studied islets from Kir6.2Y12X mice, which posses a Tyr12STOP mutation in the Kcnj11 gene, leading to premature termination of the KATP channel pore-forming subunit [48].
Positive_regulation (mutation) of Kcnj11 in pore
4) Confidence 0.36 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0 Pain Relevance 0.03

General Comments

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