INT207827

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.08
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNJ5)
KCNJ5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 40 64.08 Quite High
tetrodotoxin 50 60.96 Quite High
antagonist 40 55.20 Quite High
tolerance 10 47.84 Quite Low
Somatostatin 15 47.52 Quite Low
agonist 5 40.80 Quite Low
gABA 25 16.92 Low Low
conotoxin 60 5.00 Very Low Very Low Very Low
addiction 15 5.00 Very Low Very Low Very Low
Glutamate 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 35 77.84 Quite High
Impaired Glucose Tolerance 10 49.20 Quite Low
Hyperinsulinism 5 33.36 Quite Low
Hypoglycemia 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increasing concentrations of the KATP channel activator diazoxide demonstrated that moderate activation of KATP channels (0.3–10 ?
Positive_regulation (activation) of Gene_expression (channels) of KATP
1) Confidence 0.04 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0 Pain Relevance 0.03
cell in a dose-dependent manner through the membrane potential window supporting glucagon secretion in the depolarised (low KATP) to hyperpolarised (high KATP) direction (Figure 10C), the latter (in zero glucose) brings the ?
Positive_regulation (supporting) of Gene_expression (direction) of KATP
2) Confidence 0.04 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0 Pain Relevance 0.09
Half-maximal activation of KATP channels occurs at diazoxide concentrations of 20–100 ?
Positive_regulation (activation) of Gene_expression (channels) of KATP
3) Confidence 0.04 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0.08 Pain Relevance 0
cell in a dose-dependent manner through the membrane potential window supporting glucagon secretion in the depolarised (low KATP) to hyperpolarised (high KATP) direction (Figure 10C), the latter (in zero glucose) brings the ?
Positive_regulation (supporting) of Gene_expression (direction) of KATP
4) Confidence 0.04 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0 Pain Relevance 0.09
Moderate re-activation of KATP channels with 2 ?
Positive_regulation (activation) of Gene_expression (channels) of KATP
5) Confidence 0.04 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0 Pain Relevance 0

General Comments

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