INT207835

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.10
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GAD2) lyase activity (GAD2) Golgi apparatus (GAD2)
cytoplasmic membrane-bounded vesicle (GAD2) plasma membrane (GAD2) cytoplasm (GAD2)
GAD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 20 99.48 Very High Very High Very High
antagonist 16 78.48 Quite High
conotoxin 24 22.56 Low Low
Action potential 16 5.00 Very Low Very Low Very Low
gABA 10 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Somatostatin 6 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 2 99.16 Very High Very High Very High
Diabetes Mellitus 14 5.00 Very Low Very Low Very Low
Hypoglycemia 4 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TTX has no effect on glucose-stimulated insulin secretion in mouse islets (Figure 7A); again suggestive of a direct rather than indirect effect on ?
Positive_regulation (stimulated) of Localization (secretion) of islets associated with tetrodotoxin
1) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0 Pain Relevance 0.65
It is notable that the increase in glucagon release from the Kir6.2Y12X islets was coincident with increased insulin secretion, reinforcing the view that inhibition of glucagon is not mediated by a factor released by the ?
Positive_regulation (increase) of Localization (release) of islets associated with hyperinsulinism
2) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0.10 Pain Relevance 0

General Comments

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