INT207846

Context Info Confidence 0.06 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.14 Pain Relevance 0.04

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS) carbohydrate metabolic process (INS) cell-cell signaling (INS)

Anatomy Link Frequency brain 1 Hypism (Mus musculus) INS (Homo sapiens)

Pain Link Frequency Relevance Heat Hippocampus 2 85.00 Inflammation 10 5.00 tolerance 2 5.00 Central nervous system 1 5.00 cINOD 1 5.00 Inflammatory response 1 5.00 Intracerebroventricular 1 5.00 addiction 1 5.00 agonist 1 5.00

Disease Link Frequency Relevance Heat Hyperinsulinism 14 100.00 Insulin Resistance 103 98.20 Hypoglycemia 3 95.64 Diabetes Mellitus 24 68.56 Birth Weight 11 41.12 Disease 8 15.68 Metabolic Syndrome 46 5.00 Obesity 15 5.00 Aging 12 5.00 INFLAMMATION 12 5.00

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Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Hyperinsulinemia is known to down-regulate insulin receptor activity in peripheral tissues but not in the nervous tissue [77] and this differential loss of sensitivity presumably enhances brain activity at the cost of muscle activity.

Hyperinsulinemia Regulation (regulate) of insulin in brain associated with hyperinsulinism

1) Confidence 0.06 Published 2007 Journal BMC Evol Biol Section Body Doc Link PMC1868084 Disease Relevance 1.14 Pain Relevance 0.04

General Comments

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