INT207852

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 9.76
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (Olr1) extracellular region (Olr1) cell adhesion (Olr1)
plasma membrane (Olr1)
Anatomy Link Frequency
blood 1
plasma 1
RKO 1
skin 1
Olr1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 16 99.84 Very High Very High Very High
psoriasis 252 99.82 Very High Very High Very High
cytokine 47 93.96 High High
Inflammation 157 93.56 High High
metalloproteinase 50 84.52 Quite High
rheumatoid arthritis 4 35.68 Quite Low
cva 1 29.96 Quite Low
Inflammatory response 15 5.00 Very Low Very Low Very Low
chemokine 13 5.00 Very Low Very Low Very Low
alcohol 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 133 100.00 Very High Very High Very High
Repression 3 100.00 Very High Very High Very High
Atherosclerosis 282 99.92 Very High Very High Very High
Psoriasis 424 99.82 Very High Very High Very High
Atherosclerotic Plaque 94 99.36 Very High Very High Very High
INFLAMMATION 178 99.12 Very High Very High Very High
Malignant Neoplastic Disease 12 99.04 Very High Very High Very High
Colon Cancer 72 98.56 Very High Very High Very High
Myocardial Infarction 23 97.76 Very High Very High Very High
Disease Progression 4 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using this antibody (mAb-4E6) it is possible to measure very small amounts OxLDL containing a conformational epitope in the apoB-100 moiety of LDL that is generated as a consequence of substitution of lysine residues of apoB-100 with malondialdehyde.
Positive_regulation (generated) of OxLDL
1) Confidence 0.12 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.07 Pain Relevance 0.08
There was a positive relationship between an increased level of AuAb-oxLDL and plasma tHcy levels which may play an important role in development of atherothrombotic complications in psoriatic patients [96].
Positive_regulation (increased) of AuAb-oxLDL in plasma associated with psoriasis
2) Confidence 0.08 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 0.75 Pain Relevance 0.16
The accumulation of ox-LDL was detected in the upper epidermis of the involved skin from psoriatic patients by direct immune-fluorescent method [18].
Positive_regulation (accumulation) of ox-LDL in skin associated with psoriasis
3) Confidence 0.07 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 0.76 Pain Relevance 0.22
Phototherapy increased TC, LDL, and AuAb-oxLDL level in PASI1 patients.
Positive_regulation (increased) of AuAb-oxLDL associated with disorder of lipid metabolism
4) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.02 Pain Relevance 0.30
Patients with psoriasis exhibit increased concentrations of MDA [51, 87, 89, 90] and ox-LDL [18] in the tissues and higher levels of TBA [43, 52, 87] and anti-ox-LDL autoantibody (AuAb-oxLDL) [50, 51, 87] in the blood.
Positive_regulation (increased) of ox-LDL in blood associated with psoriasis
5) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 0.66 Pain Relevance 0.20
Unlike the normal route of LDL uptake, these receptor-mediated pathways are not regulated by cellular cholesterol content and may lead to high intracellular levels of oxLDL.
Positive_regulation (levels) of oxLDL
6) Confidence 0.03 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.59 Pain Relevance 0.03
contributing to oxLDL accumulation [22, 98].
Positive_regulation (accumulation) of oxLDL
7) Confidence 0.03 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.48 Pain Relevance 0.04
The accumulation of oxLDL
Positive_regulation (accumulation) of oxLDL
8) Confidence 0.03 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.44 Pain Relevance 0
increased levels of oxLDL have been found in the serum of patients admitted with acute myocardial infarction, and immunohistochemical studies revealed the
Positive_regulation (increased) of oxLDL associated with myocardial infarction
9) Confidence 0.03 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.90 Pain Relevance 0.13
transcriptional factor is involved in NSAID-induced 15LOX-1 induction in RKO
Positive_regulation (induction) of 15LOX-1 in RKO associated with cinod
10) Confidence 0.02 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422868 Disease Relevance 1.34 Pain Relevance 0.44
a trigger to switch 15LOX-1 repression and COX-2 upregulation along with
Positive_regulation (upregulation) of 15LOX-1 associated with repression
11) Confidence 0.02 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422868 Disease Relevance 0.76 Pain Relevance 0.26
15LOX-1 induction by nonsteroidal anti-inflammatory drugs (NSAIDs), such as
Positive_regulation (induction) of 15LOX-1 associated with inflammation and cinod
12) Confidence 0.02 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422868 Disease Relevance 1.89 Pain Relevance 0.42

General Comments

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