INT207888

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.95
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 1
skin 1
Lmrq1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 1 89.52 High High
cytokine 19 5.00 Very Low Very Low Very Low
Inflammation 18 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
cryotherapy 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leishmaniasis 376 97.56 Very High Very High Very High
Infection 62 97.20 Very High Very High Very High
Disease 81 91.44 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 5 90.08 High High
Apoptosis 11 78.40 Quite High
Chlamydia Infection 9 46.32 Quite Low
Mycobacterium Infection 2 45.20 Quite Low
Brucella Infection 2 26.92 Quite Low
Malaria 4 26.20 Quite Low
Mycobacterial Infection 15 25.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These methods are sensitive enough to detect Leishmania species within sand flies.
Negative_regulation (detect) of Leishmania
1) Confidence 0.11 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872317 Disease Relevance 0.18 Pain Relevance 0
Parasitological diagnosis was achieved by direct microscopic detection of Leishmania amastigotes in Giemsa stained skin smears for patients with CL.
Negative_regulation (detection) of Leishmania in skin associated with leishmaniasis
2) Confidence 0.08 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2844367 Disease Relevance 0.53 Pain Relevance 0.09
Killed Leishmania plus CpG has been shown to be a potent vaccine in mice (see Sacks, below).
Negative_regulation (vaccine) of Leishmania
3) Confidence 0.03 Published 2007 Journal Kinetoplastid Biol Dis Section Body Doc Link PMC1868746 Disease Relevance 0.34 Pain Relevance 0
We have observed that the presence of ATPe during L. amazonensis infection does not interfere with Leishmania invasion, but the ATPe treatment of macrophages that are already infected with L. amazonensi leads to a decrease in Leishmania survival (our unpublished observations).
Negative_regulation (decrease) of Leishmania in macrophages associated with infection
4) Confidence 0.01 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096763 Disease Relevance 0.64 Pain Relevance 0
At present the vaccines shown to be effective in protecting animals are: a whole killed parasite +/- adjuvants (first generation vaccine); a purified or recombinant vaccine (protein or DNA) plus adjuvant; a live attenuated Leishmania; and a live virulent L. major.
Negative_regulation (attenuated) of Leishmania
5) Confidence 0.01 Published 2007 Journal Kinetoplastid Biol Dis Section Body Doc Link PMC2000869 Disease Relevance 1.25 Pain Relevance 0

General Comments

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