INT207891

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.87
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
face 2
stigma 1
reservoir 1
Lmrq1 (Mus musculus)
Pain Link Frequency Relevance Heat
headache 2 50.28 Quite High
cryotherapy 4 44.96 Quite Low
abdominal pain 4 41.04 Quite Low
cytokine 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leishmaniasis 416 100.00 Very High Very High Very High
Infection 116 100.00 Very High Very High Very High
Disease 112 100.00 Very High Very High Very High
Cicatrix 20 98.12 Very High Very High Very High
Congenital Anomalies 4 86.32 High High
Urticaria 4 79.28 Quite High
Sprains And Strains 4 63.20 Quite High
Neglected Diseases 22 61.64 Quite High
Diarrhoea 4 60.88 Quite High
Vomiting 10 57.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, Leishmania infection specifically causes an increase in vector biting persistence on mice (re-feeding after interruption) and also promotes feeding on multiple hosts.
Positive_regulation (promotes) of Gene_expression (infection) of Leishmania associated with infection
1) Confidence 0.28 Published 2007 Journal PLoS Pathogens Section Abstract Doc Link PMC1904410 Disease Relevance 0.24 Pain Relevance 0
We describe an elegant and novel example of behavioral manipulation in which the timing of parasite development is linked to the feeding persistence of the sand fly vector and demonstrate that such a strategy enhances Leishmania transmission.


Positive_regulation (enhances) of Gene_expression (transmission) of Leishmania
2) Confidence 0.28 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1904410 Disease Relevance 0.14 Pain Relevance 0
The global burden of cutaneous leishmaniasis was discussed with respect to

• Financial impact on the lives of CL cases, who in general are amongst the most under privileged population in endemic countries – the close association between poverty and CL incidence in many countries was noted • The stigma associated with the lesion and scar of CL, particularly in young women leading to suffering and marginalization • The financial burden and its impact on health systems of disease endemic countries • Absence of a vaccine and lack of satisfactory (safe, affordable and efficacious) drugs • The diversity of epidemiological characteristics of foci of CL in Africa, Asia, Europe and Latin America due to varieties in causative Leishmania species, their vectors and mammalian reservoir hosts • Difficulties in control of CL due to lack of effective, affordable, easily implemented tools • Lack of political will and resources to maintain control activities • Lack of involvement of the pharmaceutical/biotechnology sector in the development of new drugs and vaccines

Positive_regulation (causative) of in reservoir Gene_expression (species) of Leishmania in stigma associated with leishmaniasis, cicatrix and disease
3) Confidence 0.03 Published 2007 Journal Kinetoplastid Biol Dis Section Body Doc Link PMC1868746 Disease Relevance 1.03 Pain Relevance 0
These criteria included:

• Severity of the disease, including duration of disease, average size of lesions and number of lesions per patient and severity of scars • Lack of response to available drugs • The overall incidence and prevalence of the disease (based on available data) • Sequelae of the disease, including leishmaniasis recidivans (a long-lasting relapsing form of CL often located on the face) and mucosal disease • Public health aspects, including the impact of treatment of individuals on control of transmission of Leishmania spp, the etiological agent (s) of leishmaniasis • Lack of major efforts in drug development

Positive_regulation (based) of Gene_expression (transmission) of Leishmania in face associated with leishmaniasis, cicatrix and disease
4) Confidence 0.03 Published 2007 Journal Kinetoplastid Biol Dis Section Body Doc Link PMC1868746 Disease Relevance 1.47 Pain Relevance 0
For Leishmania genus detection we have used the primers 5?
Positive_regulation (used) of Gene_expression (detection) of Leishmania
5) Confidence 0.02 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3006132 Disease Relevance 0.06 Pain Relevance 0
Additionally, the monotherapy of CL with Sbv after several decades may induce Leishmania resistance.
Spec (may) Positive_regulation (induce) of Gene_expression (resistance) of Leishmania associated with leishmaniasis
6) Confidence 0.02 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3006132 Disease Relevance 0.93 Pain Relevance 0.05

General Comments

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