INT207892

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 35
Total Number 35
Disease Relevance 26.66
Pain Relevance 6.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr9) signal transduction (Tlr9) endoplasmic reticulum (Tlr9)
plasma membrane (Tlr9) intracellular (Tlr9) lysosome (Tlr9)
Anatomy Link Frequency
B cells 4
vesicles 3
macrophages 2
Liver 1
dendritic cells 1
Tlr9 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 114 100.00 Very High Very High Very High
Opioid 57 98.82 Very High Very High Very High
Inflammation 498 98.72 Very High Very High Very High
ischemia 52 98.60 Very High Very High Very High
cytokine 445 98.20 Very High Very High Very High
agonist 98 96.48 Very High Very High Very High
Morphine 180 96.08 Very High Very High Very High
Paracetamol 31 91.76 High High
antagonist 14 89.88 High High
chemokine 191 89.20 High High
Disease Link Frequency Relevance Heat
Influenza Virus Infection 282 100.00 Very High Very High Very High
Vesicular Stomatitis 3 100.00 Very High Very High Very High
Infection 360 99.92 Very High Very High Very High
INFLAMMATION 652 99.54 Very High Very High Very High
Mycobacterial Infection 138 99.52 Very High Very High Very High
Death 83 99.04 Very High Very High Very High
Injury 339 98.86 Very High Very High Very High
Systemic Lupus Erythematosus 337 98.80 Very High Very High Very High
Cv Unclassified Under Development 51 98.60 Very High Very High Very High
Pressure And Volume Under Development 41 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLR9 is known to recognize oligonucleotide derived from M. tuberculosis genome [31].
TLR9 Binding (recognize) of associated with mycobacterial infection
1) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 1.43 Pain Relevance 0.41
The signaling of CpG starts by engagement of Toll-like receptor 9 (TLR9), followed by induction of pro-inflammatory cytokine (e.g.
TLR9 Binding (engagement) of associated with inflammation and cytokine
2) Confidence 0.38 Published 2009 Journal Pharm Res Section Body Doc Link PMC2689355 Disease Relevance 0.58 Pain Relevance 0.10
The signaling of CpG starts by engagement of Toll-like receptor 9 (TLR9), followed by induction of pro-inflammatory cytokine (e.g.
Toll-like receptor 9 Binding (engagement) of associated with inflammation and cytokine
3) Confidence 0.38 Published 2009 Journal Pharm Res Section Body Doc Link PMC2689355 Disease Relevance 0.58 Pain Relevance 0.10
Among the TLRs, TLR9 recognizes bacterial or viral DNA, although it is now known that TLR9 also recognizes unmethylated CpG-containing DNA sequences, including those of mammalian origin and synthetic ODN [4,7].
TLR9 Binding (recognizes) of
4) Confidence 0.32 Published 2009 Journal Respir Res Section Body Doc Link PMC2761862 Disease Relevance 0.80 Pain Relevance 0.14
Among the TLRs, TLR9 recognizes bacterial or viral DNA, although it is now known that TLR9 also recognizes unmethylated CpG-containing DNA sequences, including those of mammalian origin and synthetic ODN [4,7].
TLR9 Binding (recognizes) of
5) Confidence 0.32 Published 2009 Journal Respir Res Section Body Doc Link PMC2761862 Disease Relevance 0.91 Pain Relevance 0.13
The pathogen-associated molecular pattern of unmethylated bacterial DNA is recognized by TLR9, and its immunomodulatory effects can be mimicked by ODNs containing unmethylated CpG motifs [4,5].
TLR9 Binding (recognized) of
6) Confidence 0.32 Published 2009 Journal Respir Res Section Body Doc Link PMC2761862 Disease Relevance 0.91 Pain Relevance 0.05
Upon recognition of CpG-rich sequences in the endosome, TLR9, expressed by B cells, macrophages, and dendritic cells (DCs), initiates a conserved TLR family signaling cascade that begins with the recruitment of the adaptor protein MyD88, resulting in NF-?
TLR9 Binding (recognition) of in B cells
7) Confidence 0.32 Published 2009 Journal Respir Res Section Body Doc Link PMC2761862 Disease Relevance 0.87 Pain Relevance 0.12
The CpG motifs act through binding to toll-like receptor 9 (TLR-9) on B cells and plasmacytoid dendritic cells [10, 51, 52].
toll-like receptor 9 Binding (binding) of in plasmacytoid dendritic cells
8) Confidence 0.32 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.28 Pain Relevance 0
Taken together, these data reveal a role for TLR9 in the immune response to opioids during M. tuberculosis infection and provide an important example of TLR9 in host resistance to infection.


TLR9 Binding (example) of associated with mycobacterial infection, opioid and infection
9) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 2.27 Pain Relevance 0.92
Our data demonstrate a role of TLR9 in the immune responses to opioids during M. tuberculosis infection and provide an important example of TLR9 in host resistance to infection.
TLR9 Binding (example) of associated with mycobacterial infection, opioid and infection
10) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 1.00 Pain Relevance 0.89
Similarly, the ligation of TLR9 inhibits NF-?
TLR9 Binding (ligation) of
11) Confidence 0.27 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 1.51 Pain Relevance 0.28
One good example of this “injury limiting effect” is the response of conventional DCs to TLR9 ligation by DNA released from cells during ischemia-reperfusion injury.
TLR9 Binding (ligation) of associated with reperfusion injury, ischemia and injury
12) Confidence 0.27 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 1.17 Pain Relevance 0.08
Several reports have described TLR9-independent recognition of bacterial DNA [29,30].
TLR9 Binding (recognition) of
13) Confidence 0.24 Published 2009 Journal Respir Res Section Body Doc Link PMC2761862 Disease Relevance 0.49 Pain Relevance 0.24
Among the TLRs, TLR9 recognizes bacterial or viral DNA, although it is now known that TLR9 also recognizes unmethylated CpG-containing DNA sequences, including those of mammalian origin and synthetic ODN [4,7].
TLR9 Binding (recognizes) of
14) Confidence 0.24 Published 2009 Journal Respir Res Section Body Doc Link PMC2761862 Disease Relevance 0.93 Pain Relevance 0.14
Thus, dying cells release RNA, which can engage TLR3; nuclear DNA that can engage TLR9; and HMBG1 (high mobility group box protein 1) that can engage TLR4.
TLR9 Binding (engage) of
15) Confidence 0.23 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 0.86 Pain Relevance 0.20
Unmethylated CpG dinucleotides present in bacterial DNA are recognized by TLR9 [11–13], single-stranded (ss)RNA viruses, such as vesicular stomatitis virus and influenza virus are recognized by TLR7 [14], and dsRNA longer than 30 base pairs, produced during the viral replicative cycle, is recognized by TLR3 [11, 13, 15, 16].
TLR9 Binding (recognized) of associated with influenza virus infection and vesicular stomatitis
16) Confidence 0.22 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.71 Pain Relevance 0.05
Briefly, TLR2, which works with TLR1 or TLR6, recognizes bacterial components, such as lipopeptide and lipoprotein of gram-positive bacteria; specifically, the heterodimer TLR1/2 which can recognize triacyl lipopeptide, while TLR2/6 recognizes diacyl lipopeptide.TLR7 is documented to recognize RNA, while TLR9-DNA, both microbial and self [89, 90].


TLR9-DNA Binding (recognize) of
17) Confidence 0.20 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.25 Pain Relevance 0.06
Single-stranded RNA is recognized by TLR7 and TLR8, and TLR9 recognizes DNA which can be either host or pathogen derived [3].
TLR9 Binding (recognizes) of
18) Confidence 0.20 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0 Pain Relevance 0.08
Single-stranded RNA is recognized by TLR7 and TLR8, and TLR9 recognizes DNA which can be either host or pathogen derived [3].
TLR9 Binding (recognized) of
19) Confidence 0.20 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0 Pain Relevance 0.08
Furthermore, treatment with synthetic oligodeoxynucleotides that contain cytosine phosphate guanosine (CpG-ODN) motifs, known to bind to TLR9, have been suggested as possible treatment for prion diseases in a mouse model, by delaying the disease onset [105, 107].
TLR9 Binding (bind) of associated with inflammatory response, prion diseases and disease
20) Confidence 0.20 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 1.40 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox