INT207895

Context Info Confidence 0.02 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.47 Pain Relevance 0

mitochondrion (Sgpp1) Golgi apparatus (Sgpp1) endoplasmic reticulum (Sgpp1)

Anatomy Link Frequency face 2 Sgpp1 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 3 5.00 Inflammation 3 5.00 cryotherapy 2 5.00 depression 1 5.00 Pain 1 5.00 chemokine 1 5.00 agonist 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Leishmaniasis 165 100.00 Disease 43 100.00 Cicatrix 10 98.12 Neglected Diseases 11 5.00 Infection 10 5.00 Injury 7 5.00 Wound Healing 3 5.00 Cancer 3 5.00 Recurrence 3 5.00 INFLAMMATION 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These criteria included: • Severity of the disease, including duration of disease, average size of lesions and number of lesions per patient and severity of scars • Lack of response to available drugs • The overall incidence and prevalence of the disease (based on available data) • Sequelae of the disease, including leishmaniasis recidivans (a long-lasting relapsing form of CL often located on the face) and mucosal disease • Public health aspects, including the impact of treatment of individuals on control of transmission of Leishmania spp, the etiological agent (s) of leishmaniasis • Lack of major efforts in drug development

Positive_regulation (based) of Gene_expression (transmission) of spp in face associated with leishmaniasis, cicatrix and disease

1) Confidence 0.02 Published 2007 Journal Kinetoplastid Biol Dis Section Body Doc Link PMC1868746 Disease Relevance 1.47 Pain Relevance 0

General Comments

This test has worked.