INT207896

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.82
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR8) RNA binding (TLR8) intracellular (TLR8)
DNA binding (TLR8)
Anatomy Link Frequency
macrophages 1
dendritic cells 1
TLR8 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 44 96.16 Very High Very High Very High
Inflammation 18 90.56 High High
headache 2 24.12 Low Low
chemokine 22 10.40 Low Low
cryotherapy 4 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Critical Illness 74 99.56 Very High Very High Very High
Disease 118 93.24 High High
Genital Human Papilloma Virus 2 90.72 High High
INFLAMMATION 20 90.56 High High
Non-genital Cutaneous Warts 2 89.56 High High
Infection 46 85.68 High High
Leishmaniasis 330 77.48 Quite High
Death 6 72.68 Quite High
Influenza Virus Infection 30 68.00 Quite High
Dyspnea 2 26.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of TLR3, TLR4, TLR7, TLR8 and TLR9 was significantly higher in mild cases than controls (p?
Gene_expression (expression) of TLR8
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.81 Pain Relevance 0.03
Levels of TLR8 and TLR9 remained unchanged (p?
Gene_expression (Levels) of TLR8
2) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.89 Pain Relevance 0.05
Imiquimod and its more active analog, R848, are synthetic low molecular imidazoquinoline compounds which are potent immuno-modulators through activating Toll-Like Receptor7 (TLR) and TLR8 on human antigen presenting cells including macrophages and dendritic cells (Fig 9).
Gene_expression (presenting) of TLR8 in dendritic cells
3) Confidence 0.14 Published 2007 Journal Kinetoplastid Biol Dis Section Body Doc Link PMC1868746 Disease Relevance 0.56 Pain Relevance 0.09
Imiquimod and its more active analog, R848, are synthetic low molecular imidazoquinoline compounds which are potent immuno-modulators through activating Toll-Like Receptor7 (TLR) and TLR8 on human antigen presenting cells including macrophages and dendritic cells (Fig 9).
Gene_expression (presenting) of TLR8 in macrophages
4) Confidence 0.05 Published 2007 Journal Kinetoplastid Biol Dis Section Body Doc Link PMC1868746 Disease Relevance 0.56 Pain Relevance 0.09

General Comments

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