INT207897

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.52
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR8) RNA binding (TLR8) intracellular (TLR8)
DNA binding (TLR8)
Anatomy Link Frequency
macrophages 1
dendritic cells 1
TLR8 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 3 94.16 High High
Inflammation 18 88.32 High High
Central nervous system 21 87.64 High High
cytokine 48 87.28 High High
chemokine 9 11.44 Low Low
imagery 29 5.00 Very Low Very Low Very Low
Pain 18 5.00 Very Low Very Low Very Low
positron emission tomography 12 5.00 Very Low Very Low Very Low
Nerve growth factor 10 5.00 Very Low Very Low Very Low
Peripheral nervous system 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cold Sores 367 99.52 Very High Very High Very High
Infection 87 94.20 High High
Genital Human Papilloma Virus 2 92.36 High High
Non-genital Cutaneous Warts 2 91.20 High High
INFLAMMATION 21 88.32 High High
Virus Diseases 2 88.20 High High
Death 10 82.52 Quite High
Apoptosis 30 80.80 Quite High
Leishmaniasis 330 79.12 Quite High
Viral Meningitis 4 62.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The HSV TLR-dependent response entails TLR2, TLR3, TLR2/TLR6 heterodimer, TLR8 and TLR9.
Positive_regulation (entails) of TLR8 associated with cold sores
1) Confidence 0.17 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.39 Pain Relevance 0.16
Imiquimod and its more active analog, R848, are synthetic low molecular imidazoquinoline compounds which are potent immuno-modulators through activating Toll-Like Receptor7 (TLR) and TLR8 on human antigen presenting cells including macrophages and dendritic cells (Fig 9).
Positive_regulation (activating) of TLR8 in dendritic cells
2) Confidence 0.10 Published 2007 Journal Kinetoplastid Biol Dis Section Body Doc Link PMC1868746 Disease Relevance 0.56 Pain Relevance 0.09
Imiquimod and its more active analog, R848, are synthetic low molecular imidazoquinoline compounds which are potent immuno-modulators through activating Toll-Like Receptor7 (TLR) and TLR8 on human antigen presenting cells including macrophages and dendritic cells (Fig 9).
Positive_regulation (activating) of TLR8 in macrophages
3) Confidence 0.03 Published 2007 Journal Kinetoplastid Biol Dis Section Body Doc Link PMC1868746 Disease Relevance 0.56 Pain Relevance 0.09

General Comments

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