INT207899

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 1.96
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hgs) endosome (Hgs) transport (Hgs)
kinase activity (Hgs) cytoplasm (Hgs)
Anatomy Link Frequency
liver 1
nucleus 1
neutrophils 1
Hgs (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 8 94.32 High High
dexamethasone 24 84.48 Quite High
cytokine 16 61.56 Quite High
Inflammation 32 61.16 Quite High
rheumatoid arthritis 8 53.36 Quite High
spinal inflammation 8 33.00 Quite Low
Central nervous system 8 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatorenal Syndrome 5 100.00 Very High Very High Very High
Cirrhosis 3 99.20 Very High Very High Very High
Renal Failure 9 97.36 Very High Very High Very High
Liver Disease 3 96.12 Very High Very High Very High
Disease 81 89.84 High High
Injury 3 89.64 High High
Repression 32 88.00 High High
Death 8 85.24 High High
Acute Liver Failure 1 85.16 High High
Hepatotoxicity 6 82.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ligand binding of hGR?
hGR Binding (binding) of
1) Confidence 0.47 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.22 Pain Relevance 0.07
expression level is detected in some cells (e.g., human neutrophils), as compared to hGR?
hGR Binding (compared) of in neutrophils
2) Confidence 0.36 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0
In summary, the dominant-negative activity of hGR?
hGR Neg (negative) Binding (activity) of
3) Confidence 0.36 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.09 Pain Relevance 0.11
It has been shown to inhibit the activity of hGR?
hGR Binding (activity) of
4) Confidence 0.36 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.08 Pain Relevance 0.11
Although this latter activity of hGR?
hGR Binding (activity) of
5) Confidence 0.36 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0
has been shown to interact with hGR?
hGR Binding (interact) of
6) Confidence 0.35 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0
resides in the cytoplasm and only translocates to the nucleus upon ligand binding, hGR?
hGR Binding (binding) of in nucleus
7) Confidence 0.35 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0
These treatments also resulted in decreased sensitivity to glucocorticoids, as measured by reduced DNA binding of hGR?
hGR Binding (binding) of
8) Confidence 0.35 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.21 Pain Relevance 0.06
Classically, HRS is associated with the end-stage liver cirrhosis and it has been observed that renal failure occurs with this liver disease in about 50% of patients [7].
HRS Binding (associated) of in liver associated with liver disease, cirrhosis, renal failure and hepatorenal syndrome
9) Confidence 0.12 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1868763 Disease Relevance 1.36 Pain Relevance 0

General Comments

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