INT208015

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.96
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pgr) nucleus (Pgr) enzyme binding (Pgr)
DNA binding (Pgr) cytoplasm (Pgr)
Pgr (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 2 98.76 Very High Very High Very High
Inflammation 18 75.04 Quite High
Inflammatory marker 1 43.12 Quite Low
cytokine 3 27.84 Quite Low
Inflammatory mediators 3 17.92 Low Low
fibrosis 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 8 97.40 Very High Very High Very High
Hyperplasia 3 96.12 Very High Very High Very High
Sprains And Strains 47 83.52 Quite High
Premature Birth 54 80.60 Quite High
Cancer 21 80.36 Quite High
Peripheral Arterial Disease 2 75.20 Quite High
INFLAMMATION 23 75.04 Quite High
Pre-term Labor 9 56.04 Quite High
Rupture 1 50.56 Quite High
Necrosis 1 40.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
overexpression, increased PR levels were also observed.
Positive_regulation (overexpression) of Positive_regulation (increased) of PR
1) Confidence 0.35 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.65 Pain Relevance 0
Binding of progesterone to PR-A, the short form of the receptor, not thought to be associated with intra-cellular pathway mechanisms, prevents the actions of progesterone mediated by PR-B.71 An increase in the myometrial PR-A to PR-B expression ratio occurs at the onset of labor at term, resulting in an increase in myometrial PR-A, and in effect a functional withdrawal of progesterone,71,72 with increasing sensitivity to contractile stimuli.65,67,73,74 Prostaglandins produced prior to the onset of labor, also act to increase the PR-A/PR-B expression ratio, and therefore the potential to initiate a functional withdrawal of progesterone.67 In many animals the onset of labor is associated with a decrease in progesterone concentrations,62,64,65,75 but this has not been shown to occur in women before term or preterm birth, with no apparently detectable changes to circulating steroid hormone levels evident.64,65,67,76,77

Progesterone as an anti-inflammatory agent

Positive_regulation (resulting) of Positive_regulation (increase) of PR associated with inflammation, premature birth and withdrawal
2) Confidence 0.26 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971700 Disease Relevance 0.32 Pain Relevance 0.13

General Comments

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