INT20804

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Context Info
Confidence 0.45
First Reported 1990
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.33
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCK) extracellular space (CCK) extracellular region (CCK)
Anatomy Link Frequency
SK-N-MC 4
plasma 2
neuron 2
CCK (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 153 100.00 Very High Very High Very High
noradrenaline 7 90.16 High High
Enkephalin 5 88.08 High High
Neuropeptide 7 87.28 High High
agonist 2 84.16 Quite High
tolerance 1 74.60 Quite High
antagonist 7 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Opioid 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Critical Illness 91 99.84 Very High Very High Very High
Neuroblastoma 2 97.92 Very High Very High Very High
Peripheral Primitive Neuroectodermal Tumors 2 82.28 Quite High
Eating Disorder 2 55.36 Quite High
Appetite Loss 4 53.68 Quite High
Body Weight 5 29.28 Quite Low
Gastric Motility Disorder 8 5.04 Very Low Very Low Very Low
Sleep Disorders 5 5.00 Very Low Very Low Very Low
Obesity 5 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observation that the rate of GE is inversely related to the fasting levels of CCK and PYY suggests that they may contribute to the regulation of GE in critically ill patients.
Regulation (related) of Gene_expression (levels) of CCK associated with critical illness and cholecystokinin
1) Confidence 0.45 Published 2007 Journal Crit Care Section Body Doc Link PMC2246231 Disease Relevance 0.72 Pain Relevance 0.21
These results suggest that expression of proCCK and proenkephalin A mRNA may be regulated by a similar cAMP-dependent mechanism in the SK-N-MC cell line.
Regulation (regulated) of Gene_expression (expression) of proCCK in SK-N-MC
2) Confidence 0.44 Published 1990 Journal J. Mol. Endocrinol. Section Abstract Doc Link 2157452 Disease Relevance 0.07 Pain Relevance 0.16
Regulation of the expression of procholecystokinin (proCCK) and proenkephalin A mRNA was studied in the human neuroblastoma cell line SK-N-MC.
Regulation (Regulation) of Gene_expression (expression) of proCCK in SK-N-MC associated with neuroblastoma
3) Confidence 0.44 Published 1990 Journal J. Mol. Endocrinol. Section Abstract Doc Link 2157452 Disease Relevance 0.10 Pain Relevance 0.15
Relationship between plasma PYY and CCK concentrations in critical illness
Regulation (Relationship) of Gene_expression (concentrations) of CCK in plasma associated with critical illness and cholecystokinin
4) Confidence 0.43 Published 2006 Journal Crit Care Section Body Doc Link PMC1794491 Disease Relevance 0.28 Pain Relevance 0.39
This clonal neuronal cell line provides a unique model system to identify cis- and trans-acting factors responsible for neuron-specific expression and regulation of the CCK gene.
Regulation (responsible) of Gene_expression (expression) of CCK in neuron associated with cholecystokinin
5) Confidence 0.27 Published 1990 Journal FEBS Lett. Section Abstract Doc Link 2384178 Disease Relevance 0.16 Pain Relevance 0.64

General Comments

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