INT20810

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Context Info
Confidence 0.44
First Reported 1990
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.91
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MYCN) DNA binding (MYCN)
Anatomy Link Frequency
muscle tissue 1
DRG 1
MYCN (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 4 99.30 Very High Very High Very High
noradrenaline 3 92.88 High High
agonist 1 80.04 Quite High
Action potential 1 71.28 Quite High
qutenza 2 39.52 Quite Low
Pain 1 25.00 Low Low
Enkephalin 1 25.00 Low Low
nociceptor 1 25.00 Low Low
withdrawal 1 19.36 Low Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 4 99.30 Very High Very High Very High
Retinoblastoma 4 96.86 Very High Very High Very High
Nociception 2 75.00 Quite High
Neuroblastoma 1 74.44 Quite High
Infection 28 73.32 Quite High
Apoptosis 32 51.96 Quite High
Rhinitis 12 7.96 Low Low
Injury 9 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The level of proenkephalin A mRNA increased approximately two to three times under the same drug conditions, whereas the level of N-myc mRNA did not change significantly.
Neg (not) Regulation (change) of N-myc
1) Confidence 0.44 Published 1990 Journal J. Mol. Endocrinol. Section Abstract Doc Link 2157452 Disease Relevance 0.07 Pain Relevance 0.16
We report here the development of an immortalized human dorsal root ganglion (DRG) clonal cell line, HD10.6, with a tetracycline-regulatable v-myc oncogene.
Regulation (tetracycline-regulatable) of v-myc oncogene in DRG associated with ganglion cysts and dorsal root ganglion
2) Confidence 0.28 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10377351 Disease Relevance 0.35 Pain Relevance 0.17
As shown in Table 3, expression change of many cell cycle-related factors was observed in Trichinella infected muscle tissue, for example, retinoblastoma (Rb), CDK4, cyclin C, cyclin B2, cyclin D2 and cyclin D3, CLU, G0/G1 switch gene 2 (G0S2), inhibitor of DNA binding 2 (Id2), myeloblastosis oncogene (Myb), and N-myc downstream regulated gene 2 (Ndrg2) [9,11].
Regulation (regulated) of N-myc in muscle tissue associated with retinoblastoma
3) Confidence 0.01 Published 2008 Journal Parasit Vectors Section Body Doc Link PMC2538513 Disease Relevance 0.49 Pain Relevance 0

General Comments

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