INT208108

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Context Info
Confidence 0.70
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 1.50
Pain Relevance 5.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
synapses 3
hippocampus 2
brain 1
forebrain 1
ACC neurons 1
Grin2a (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 357 100.00 Very High Very High Very High
antagonist 67 99.96 Very High Very High Very High
Dorsal horn 49 99.48 Very High Very High Very High
Anterior cingulate cortex 71 99.12 Very High Very High Very High
Hippocampus 139 98.36 Very High Very High Very High
Dorsal horn neuron 30 96.52 Very High Very High Very High
long-term potentiation 379 93.52 High High
Pain 57 90.24 High High
Pyramidal cell 56 88.52 High High
cytokine 3 86.80 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 143 99.28 Very High Very High Very High
Anxiety Disorder 32 91.84 High High
Pain 106 90.24 High High
Congenital Anomalies 50 88.24 High High
Depression 181 82.48 Quite High
Shock 12 76.04 Quite High
Repression 1 62.00 Quite High
Drug Dependence 31 50.00 Quite Low
Disseminated Intravascular Coagulation 22 48.32 Quite Low
Substance Withdrawal Syndrome 8 47.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M is likely to be relatively selective for NR2A-containing NMDARs in ACC neurons.


Localization (selective) of NR2A in ACC neurons associated with anterior cingulate cortex
1) Confidence 0.70 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0.08 Pain Relevance 0.37
The data suggest that PSD-93 is required for synaptic expression and localization of NR2A and NR2B in dorsal horn and forebrain cortex.
Localization (localization) of NR2A in forebrain associated with dorsal horn
2) Confidence 0.60 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.29 Pain Relevance 0.45
The absence of Neto1 had no effect on the overall abundance of NR1, NR2A, NR2B, PSD-95, GluR2, VAMP2, or GABAAR1 proteins (Figure 6L) in whole brain extracts, or of NR1, NR2A, NR2B, or PSD-95 in crude synaptosomes (Figure 6M).
Localization (abundance) of NR2A in brain
3) Confidence 0.55 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.17 Pain Relevance 0.05
To determine whether the decreased synaptic abundance of NR2A subunits leads to a reduction in NR2A-mediated synaptic currents we examined the relative contribution of NR2A versus NR2B to NMDAR EPSCs at CA1 synapses.
Localization (abundance) of NR2A in synapses
4) Confidence 0.55 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.15
Although Neto1 binds to both NR2A and NR2B, the loss of Neto1 leads to a reduction in the abundance of NR2A, but not NR2B, in the PSD fraction from hippocampus and a reduction in NR2A puncta in the CA1 region.
Localization (abundance) of NR2A in hippocampus associated with hippocampus
5) Confidence 0.55 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.09
Taken together, these findings demonstrate that Neto1 is required for the normal abundance of synaptic NR2A-containing NMDARs and, as a result, for the normal contribution of NR2A-NMDARs to synaptic transmission and plasticity in CA1 hippocampus.


Localization (contribution) of NR2A in hippocampus associated with hippocampus
6) Confidence 0.55 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.09
These results indicate that both NR2A and NR2B-containing NMDA receptors were impaired in transgenic CA1 hippocampal neurons.


Localization (receptors) of NR2A in neurons associated with targeted disruption and nmda receptor
7) Confidence 0.53 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.16 Pain Relevance 0.56
m, visual experience was manipulated in mice with a fixed ratio due to genetic deletion of NR2A (Philpot et al. 2007).
Localization (deletion) of NR2A
8) Confidence 0.48 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674473 Disease Relevance 0.08 Pain Relevance 0.23
The deletion of NR2A was found to both mimic and occlude the effects of dark rearing on the amplitude, decay kinetics and temporal summation of NMDA currents.
Localization (deletion) of NR2A
9) Confidence 0.48 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674473 Disease Relevance 0.08 Pain Relevance 0.23
Consistent with the reduction in NR2A protein in the PSDs of Neto1-null mice, which had no change in total NR2A abundance in whole brain, we identified a decrease in NMDAR EPSCs at Schaffer collateral-CA1 synapses, which are normally dominated by NR2A-containing receptors [40].
Localization (abundance) of NR2A in synapses
10) Confidence 0.48 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.09
These findings indicate that Neto1 is required to establish or maintain the normal abundance of NR2A-containing NMDARs in the PSD.
Localization (abundance) of NR2A-containing
11) Confidence 0.48 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.06
We investigated the impact of the decrease of synaptic NR2A-mediated currents on tbLTP at Schaffer collateral synapses.
Localization (decrease) of NR2A in synapses
12) Confidence 0.48 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.03
20HA co-immunoprecipitated with both NR2A (Figure 5A, lanes 1 and 2, and Figure 5C, lane 4) and NR2B (Figure 5B, lanes 1 and 2, and Figure 5C, lane 5) expressed in the absence of NR1 and PSD-95.
Localization (immunoprecipitated) of NR2A
13) Confidence 0.48 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
These results support our interpretation that both types of NR2 subunits, NR2A/B and NR2C/D are present on inhibitory interneurons of lamina II.
Localization (types) of NR2 in lamina
14) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.24
Pharmacological test of NR2 subunit confirms the expression of NR2A/B and NR2C/D type NMDA receptors
Localization (test) of NR2 subunit associated with nmda receptor
15) Confidence 0.40 Published 2008 Journal Mol Pain Section Body Doc Link PMC2572590 Disease Relevance 0 Pain Relevance 0.35
Bath application of a NR2A antagonist NVP-AAM077 and NR2B antagonist ifenprodil/Ro compounds produce almost completely blockade of NMDA receptor mediated EPSCs.
Localization (application) of NR2A associated with nmda receptor and antagonist
16) Confidence 0.27 Published 2007 Journal Mol Pain Section Body Doc Link PMC1904186 Disease Relevance 0.34 Pain Relevance 1.19
These data suggests that leptin does not promote the translocation of NR2A-containing NMDA receptors into dendritic filopodia.


Localization (translocation) of NR2A associated with nmda receptor
17) Confidence 0.26 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0.30
Thus, as the leptin-induced formation of dendritic filopodia is dependent on the activation of NR2A-containing NMDA receptors, the effects of leptin on the localization of NR2A subunits was also examined.
Localization (localization) of NR2A associated with nmda receptor
18) Confidence 0.26 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0.30
The data suggest that PSD-93 is required for synaptic expression and localization of NR2A and NR2B in dorsal horn and forebrain cortex.
Localization (localization) of NR2A in dorsal horn associated with dorsal horn
19) Confidence 0.21 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.29 Pain Relevance 0.45

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