INT208121

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.06
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2a, Grin2b) plasma membrane (Grin2a, Grin2b) embryo development (Grin2b)
locomotion (Grin2a)
Anatomy Link Frequency
lamina 1
Grin2a (Mus musculus)
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 173 95.20 Very High Very High Very High
Dorsal horn neuron 6 80.60 Quite High
Hippocampus 14 65.64 Quite High
Spinal cord 16 61.84 Quite High
Lasting pain 7 61.16 Quite High
Anterior cingulate cortex 17 56.44 Quite High
antagonist 55 39.40 Quite Low
long-term potentiation 26 35.68 Quite Low
GABAergic 28 25.36 Quite Low
Dorsal horn 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 15 61.16 Quite High
Neuropathic Pain 10 5.00 Very Low Very Low Very Low
Cognitive Disorder 8 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 7 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low
Nervous System Injury 6 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternatively, it has been proposed that there are potential interactions for NR2A and NR2B [27], which may also account for the variability.
NR2A Binding (interactions) of NR2B
1) Confidence 0.35 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0.06 Pain Relevance 0.22
After endocytosis, NR2A and NR2B sort into different intracellular pathways, with NR2B preferentially trafficking to recycling endosomes.
NR2A Binding (trafficking) of NR2B
2) Confidence 0.19 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
During postnatal development, NR2B is replaced by other NR2 subunits [10].
NR2 Binding (replaced) of NR2B
3) Confidence 0.18 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.11
Therefore, it is possible that NR2B subunits are expressed in lamina II interneurons at early stages of development and are replaced by NR2A receptors during maturation.
NR2A Binding (replaced) of NR2B in lamina
4) Confidence 0.18 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox