INT208125

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.06
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 8.15
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DDR1) cell adhesion (DDR1) plasma membrane (DDR1)
Anatomy Link Frequency
fibroblasts 2
Nerve 1
HGF 1
DDR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 7 100.00 Very High Very High Very High
Nerve growth factor 5 100.00 Very High Very High Very High
cytokine 18 99.38 Very High Very High Very High
Somatostatin 2 99.28 Very High Very High Very High
endometriosis 108 99.14 Very High Very High Very High
Inflammation 12 92.84 High High
Pain 8 86.96 High High
Cannabinoid 30 81.20 Quite High
metalloproteinase 4 79.92 Quite High
cocaine 1 70.68 Quite High
Disease Link Frequency Relevance Heat
Cancer 130 100.00 Very High Very High Very High
Adhesions 46 100.00 Very High Very High Very High
Necrosis 14 100.00 Very High Very High Very High
Keloid Scars 140 99.98 Very High Very High Very High
Endometriosis 138 99.14 Very High Very High Very High
Disease 69 99.12 Very High Very High Very High
Cicatrix 20 97.40 Very High Very High Very High
Hepatitis C Virus Infection 3 96.80 Very High Very High Very High
Injury 33 96.58 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 69 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The RET receptor tyrosine kinase (RTK)
Gene_expression (The) of RTK
1) Confidence 0.06 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.01 Pain Relevance 0.04
Chronic dermal wounds consist of fibroblasts that overproduce collagen and chondroitin sulfate, have high contractile activity, high levels of secreted cytokines, and are similar to tumors in overexpression of RTK, a transmembrane receptor that binds to growth factors such as fibroblast growth factor (FGF) (Mancini and Quaife 1962; Berman and Bieley 1995).
Gene_expression (overexpression) of RTK in fibroblasts associated with cancer, injury and cytokine
2) Confidence 0.05 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2426758 Disease Relevance 1.17 Pain Relevance 0.18
SF-ELP also decreased survival rate of keloids that expressed high levels of RTK.
Gene_expression (expressed) of RTK associated with keloid scars
3) Confidence 0.05 Published 2006 Journal International Journal of Nanomedicine Section Abstract Doc Link PMC2426758 Disease Relevance 0.61 Pain Relevance 0
Keloids express abundant levels of mucopolysaccharides and receptor tyrosine kinase (RTK).
Gene_expression (express) of RTK associated with keloid scars
4) Confidence 0.05 Published 2006 Journal International Journal of Nanomedicine Section Abstract Doc Link PMC2426758 Disease Relevance 0.56 Pain Relevance 0
While the INCB overtly concludes that the NEP are technically allowed this does not mean that the Board, in actuality, entirely supportive of this harm reduction measure.
Gene_expression (allowed) of NEP
5) Confidence 0.04 Published 2007 Journal Harm Reduct J Section Body Doc Link PMC1871577 Disease Relevance 0.46 Pain Relevance 0.04
To observe if the SF coating increased adhesion of the liposomes to target cells, ELP and SF-ELP were added to normal and keloid fibroblasts, which express normal and high levels of RTK, respectively.
Gene_expression (express) of RTK in fibroblasts associated with keloid scars and adhesions
6) Confidence 0.04 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2426758 Disease Relevance 0.98 Pain Relevance 0
As previously stated, keloids overexpress RTK and are targeted by emodin, while the overexpression of the muco-polysaccharides over the cell surface would have attraction for the SF (Berman and Bieley 1995; Mancini and Quaife 1962).


Gene_expression (overexpress) of RTK associated with keloid scars
7) Confidence 0.04 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2426758 Disease Relevance 0.70 Pain Relevance 0
However, except for a report showing an increase in c-Met (RTK) and HGF (ligand) in endometriosis [56], there has been little evidence that RTK are overexpressed or activated in this disease.


Gene_expression (overexpressed) of RTK in HGF associated with endometriosis and disease
8) Confidence 0.03 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.21 Pain Relevance 0.41
Additionally, CB1 and CB2 receptors have been shown to be coupled to other intracellular cascades, including the mitogen-activated protein kinase cascade, the phosphatidylinositol 3-kinase, the focal adhesion kinase, ceramide signaling and nitric oxide production [14, 42, 62, 88, 142, 171].
Gene_expression (production) of adhesion kinase associated with adhesions
9) Confidence 0.01 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644494 Disease Relevance 0.10 Pain Relevance 0.14
Treatment with imipramine resulted in significant up-regulation of three (Glial cell line derived neurotrophic factor superfamily receptor alpha 2, Macrophage expressed gene 1, Tumor necrosis factor member 11), 13 (Nerve growth factor beta, tumor necrosis factor receptor regulator, Jun D proto-oncogene, Adenosine A1 receptor, Neurotrophic tyrosine kinase receptor type 2, Somatostatin receptor 5, Leptin receptor, Arrestin beta 1, Epsin 1, Caspase 8, Cyclin-dependent kinase 5, Synuclein alpha, Amyloid beta precursor protein), and five (Transforming growth factor beta 2, RAB6A member RAS oncogene family, Regucalcin, Syntaxin 11, Homogentisate 1, 2-dioxygenase) genes and down-regulation of five (Leukocyte cell derived chemotaxin 1, Phospholipase A2 activating protein, Mitogen-activated protein kinase), one (Interferon gamma), and two (Tumor necrosis factor alpha induced protein 6, Granzyme A) genes after one, three and seven days of treatment, respectively.
Gene_expression (expressed) of Neurotrophic tyrosine kinase in Nerve associated with necrosis, adenocard, nerve growth factor, cancer, alzheimer's dementia and somatostatin
10) Confidence 0.01 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 1.36 Pain Relevance 0.23

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox