INT208140

Context Info Confidence 0.73 First Reported 2007 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 5 Disease Relevance 6.18 Pain Relevance 0.14

nucleolus (PITX1) nucleus (PITX1) protein binding transcription factor activity (PITX1) cytoplasm (PITX1)

Anatomy Link Frequency veins 1 PITX1 (Homo sapiens)

Pain Link Frequency Relevance Heat cva 28 84.64 imagery 40 5.00 headache 9 5.00 ischemia 8 5.00 Pain 8 5.00 medulla 4 5.00

Disease Link Frequency Relevance Heat Heart Failure 233 100.00 Glaucoma 48 99.58 Fistula 92 96.16 Retina Disease 24 95.60 Hemorrhage 4 94.80 Thrombosis 20 93.84 Ocular Toxicity (including Many Sub-types) 16 92.72 Ocular Hypertension 40 89.08 Exophthalmos 64 88.36 Ophthalmoplegia 16 87.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, SOV embolization in the management of CCF may be associated with vision-threatening complications.

Localization (embolization) of CCF associated with heart failure

1) Confidence 0.73 Published 2009 Journal Middle East African Journal of Ophthalmology Section Body Doc Link PMC2813585 Disease Relevance 1.54 Pain Relevance 0.04

Although the SOV is a useful route for CCF embolization, the presence of fragile or clotted veins can preclude successful cannulation.

Localization (embolization) of CCF in veins associated with heart failure

2) Confidence 0.63 Published 2009 Journal Middle East African Journal of Ophthalmology Section Body Doc Link PMC2813585 Disease Relevance 1.60 Pain Relevance 0.04

Embolization of CCF may carry a risk of inherent complication either from the procedure or due to reopening of the fistula.

Localization (Embolization) of CCF associated with fistula and heart failure

3) Confidence 0.63 Published 2009 Journal Middle East African Journal of Ophthalmology Section Body Doc Link PMC2813585 Disease Relevance 0.88 Pain Relevance 0.03

Kikkawa et al.32 reported a case of a 69-year-old man who developed unilateral vision loss and neovascular glaucoma after attempted SOV embolization in the treatment of a CCF.

Localization (embolization) of CCF associated with glaucoma and heart failure

4) Confidence 0.63 Published 2009 Journal Middle East African Journal of Ophthalmology Section Body Doc Link PMC2813585 Disease Relevance 1.56 Pain Relevance 0.04

CCF-Kenya is supported by sponsors for 44,000 individual children from around the world and operates in 30 districts of Kenya.

Localization (supported) of CCF-Kenya associated with heart failure

5) Confidence 0.49 Published 2007 Journal Malar J Section Body Doc Link PMC1871595 Disease Relevance 0.60 Pain Relevance 0

General Comments

This test has worked.