INT208142

Context Info Confidence 0.65 First Reported 2007 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 6 Disease Relevance 9.36 Pain Relevance 0.73

nucleolus (PITX1) nucleus (PITX1) protein binding transcription factor activity (PITX1) cytoplasm (PITX1)

Anatomy Link Frequency sinus 2 muscles 1 PITX1 (Homo sapiens)

Pain Link Frequency Relevance Heat imagery 40 99.96 cva 28 95.56 Pain 9 88.00 medulla 4 63.80 headache 9 40.96 ischemia 8 5.00 Sicca syndrome 1 5.00 tolerance 1 5.00

Disease Link Frequency Relevance Heat Heart Failure 233 100.00 Cancer 13 100.00 Brain Hemorrhage 12 100.00 Congenital Anomalies 9 100.00 Cavernous Sinus Thrombosis 8 100.00 Mucocele 4 100.00 Cerebral Aneurysm 4 100.00 Mycobacterial Infection 6 99.80 Phycomycosis 4 99.46 Eye Disease 4 99.20

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Infections such as orbital cellulitis, mucormycosis and tuberculosis may also present as CCF.

Gene_expression (present) of CCF associated with mycobacterial infection, orbital cellulitis, phycomycosis, heart failure and infection

1) Confidence 0.65 Published 2009 Journal Middle East African Journal of Ophthalmology Section Body Doc Link PMC2813585 Disease Relevance 2.29 Pain Relevance 0.21

Some of the differential diagnoses for CCF include vascular lesions such as arteriovenous malformation and cavernous sinus thrombosis, cavernous sinus tumors, orbital tumors, skull base tumors and mucocele.521 Mendicino et al.3 reviewed ocular manifestations of the most common intracranial vascular abnormalities: intracranial aneurysms, CCF, arteriovenous malformations and cavernous malformations.

Gene_expression (aneurysms) of CCF in sinus associated with cavernous sinus thrombosis, brain hemorrhage, cerebral aneurysm, congenital anomalies, cancer, mucocele and heart failure

2) Confidence 0.57 Published 2009 Journal Middle East African Journal of Ophthalmology Section Body Doc Link PMC2813585 Disease Relevance 2.24 Pain Relevance 0.14

Some of the differential diagnoses for CCF include vascular lesions such as arteriovenous malformation and cavernous sinus thrombosis, cavernous sinus tumors, orbital tumors, skull base tumors and mucocele.521 Mendicino et al.3 reviewed ocular manifestations of the most common intracranial vascular abnormalities: intracranial aneurysms, CCF, arteriovenous malformations and cavernous malformations.

Gene_expression (aneurysms) of CCF in sinus associated with cavernous sinus thrombosis, brain hemorrhage, cerebral aneurysm, congenital anomalies, cancer, mucocele and heart failure

3) Confidence 0.57 Published 2009 Journal Middle East African Journal of Ophthalmology Section Body Doc Link PMC2813585 Disease Relevance 2.16 Pain Relevance 0.13

On imaging studies such as CT scan and MRI, CCF may present with enlarged SOV, thick extraocular muscles and evidence of enlarged cavernous sinus with a convexity of the lateral wall (Figures 2C and 2D 3C and 3D).1024 These changes can only make one suspect a fistula.

Gene_expression (present) of CCF in muscles associated with fistula, imagery and heart failure

4) Confidence 0.57 Published 2009 Journal Middle East African Journal of Ophthalmology Section Body Doc Link PMC2813585 Disease Relevance 1.77 Pain Relevance 0.16

CCF-enrolled households belonged predominantly to the lower socio-economic levels including 76% of all respondents without formal education (68 out of 90) and only 4% of respondents had a college degree (one out of 23), indicating that the CCF programme's targeting strategy is well implemented.

Gene_expression (programme) of CCF associated with heart failure

5) Confidence 0.38 Published 2007 Journal Malar J Section Body Doc Link PMC1871595 Disease Relevance 0.20 Pain Relevance 0

3), cell cycle (cyclin D1), arachidonic acid hydroxylation (cytochrome P450, family 4, subfamily F, polypeptide 12), cysteine protease inhibition (calpastatin), prolactin regulation (paired-like homeodomain 1) and a variety of cellular processes associated with G protein signaling (GTP-binding protein 10).

Gene_expression (paired) of homeodomain 1

6) Confidence 0.07 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790476 Disease Relevance 0.71 Pain Relevance 0.09

General Comments

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