INT208225

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.84
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TSHR) cell-cell signaling (TSHR) signal transducer activity (TSHR)
Anatomy Link Frequency
eye 4
adipocytes 2
TSHR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 3 99.60 Very High Very High Very High
flare ups 1 83.32 Quite High
Inflammation 26 62.96 Quite High
cytokine 6 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroiditis 66 100.00 Very High Very High Very High
Graves' Ophthalmopathy 65 100.00 Very High Very High Very High
Disease 28 100.00 Very High Very High Very High
Obesity 5 100.00 Very High Very High Very High
Thyroid Disease 47 99.24 Very High Very High Very High
Hyperthyroidism 8 98.00 Very High Very High Very High
Autoimmune Disease 44 86.88 High High
Nicotine Addiction 5 86.68 High High
Exophthalmos 13 78.44 Quite High
Hypothyroidism 2 74.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the TSH-r is also expressed in fibroblasts and adipocytes at sites such as the abdominal wall which are unaffected in Graves’ disease patients.16 In patients with Hashimoto’s thyroiditis, eye changes occur in the presumed absence of TSH-r antibody production.
Positive_regulation (absence) of Gene_expression (production) of TSH-r in eye associated with thyroiditis, graves' ophthalmopathy, obesity and disease
1) Confidence 0.46 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 1.06 Pain Relevance 0.03
Furthermore, the TSH-r is also expressed in fibroblasts and adipocytes at sites such as the abdominal wall which are unaffected in Graves’ disease patients.16 In patients with Hashimoto’s thyroiditis, eye changes occur in the presumed absence of TSH-r antibody production.
Positive_regulation (occur) of Gene_expression (expressed) of TSH-r in eye associated with thyroiditis, graves' ophthalmopathy, obesity and disease
2) Confidence 0.43 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 1.18 Pain Relevance 0.06
by its agonist, TZD, was shown to stimulate functional TSHr expression, and also to induce the recruitment and differentiation of orbital fibroblasts into mature lipid-laden adipocytes [7-9].
Positive_regulation (stimulate) of Gene_expression (expression) of TSHr in adipocytes associated with obesity and agonist
3) Confidence 0.18 Published 2007 Journal BMC Ophthalmol Section Body Doc Link PMC1876204 Disease Relevance 0.60 Pain Relevance 0.13

General Comments

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