INT208243

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.74
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
nucleus 2
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 103 100.00 Very High Very High Very High
agonist 15 99.82 Very High Very High Very High
antidepressant 45 96.56 Very High Very High Very High
Desipramine 49 82.48 Quite High
fluoxetine 47 81.28 Quite High
chemokine 8 69.60 Quite High
tolerance 9 66.28 Quite High
antagonist 17 64.80 Quite High
cytokine 25 52.80 Quite High
adenocard 73 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 93 100.00 Very High Very High Very High
Bacterial Infection 8 99.80 Very High Very High Very High
Cancer 85 98.68 Very High Very High Very High
Necrosis 4 98.44 Very High Very High Very High
Pneumonia 23 98.24 Very High Very High Very High
Sepsis 28 95.04 Very High Very High Very High
Metastasis 46 93.44 High High
Skin Cancer 8 93.00 High High
Injury 37 92.92 High High
Infection 4 86.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results are consensually supported by the studies in which TLR4 activation inhibits phosphorylation and nucleus translocation of Stat3 [21] and activated Stat3 inhibits TLR4 signaling in return via inhibiting transcriptional or translational activity of NF-?
Positive_regulation (activation) of Phosphorylation (phosphorylation) of TLR4 in nucleus
1) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.28 Pain Relevance 0.12
As shown in Figure 2C, pretreatment with TLR4 antibody also inhibited LPS-stimulated phosphorylation of NF-?
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of LPS
2) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.15 Pain Relevance 0.04
NO radical increased gradually at 2 h and increased rapidly at 4 h after LPS injection.
Positive_regulation (increased) of Phosphorylation (injection) of LPS
3) Confidence 0.25 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386525 Disease Relevance 0.83 Pain Relevance 0.04
In addition, the same A2A agonist reduced LPS-induced microvascular permeability and secretion of interleukin-6, tumor necrosis factor-?
Positive_regulation (induced) of Phosphorylation (permeability) of LPS associated with necrosis, cancer and agonist
4) Confidence 0.07 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 1.04 Pain Relevance 0.44
LPS-induced inflammation and endotoxic shock in mice
Positive_regulation (induced) of Phosphorylation (inflammation) of LPS associated with inflammation and bacterial infection
5) Confidence 0.03 Published 2007 Journal Respir Res Section Body Doc Link PMC1876225 Disease Relevance 0.42 Pain Relevance 0.22

General Comments

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