INT208267

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.27
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGIP)
IGIP (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 10 71.28 Quite High
Inflammation 35 30.96 Quite Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 24 99.16 Very High Very High Very High
Cancer 106 95.88 Very High Very High Very High
Colon Cancer 1 75.52 Quite High
Pulmonary Fibrosis 6 71.28 Quite High
Skin Cancer 1 47.36 Quite Low
Carcinoma 1 35.20 Quite Low
INFLAMMATION 35 30.96 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 23.20 Low Low
Lobular Carcinoma 1 10.04 Low Low
Asthma 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, interferon gamma-inducible proteosome regulator IGIP/PA28, an important modulator of immunoproteosome formation and function, was increased nearly 4-fold (Fig. 4C and Table 1).
Positive_regulation (increased) of IGIP
1) Confidence 0.67 Published 2007 Journal Respir Res Section Body Doc Link PMC1876226 Disease Relevance 0.21 Pain Relevance 0
Other proteins, like ANXV, ANXVI, IGIP/PA28, and HABP-1, were increased at 24 hours and remained highly elevated at 96 hours – and indication that heparin has more extended effects on selected proteins.


Positive_regulation (increased) of IGIP
2) Confidence 0.45 Published 2007 Journal Respir Res Section Body Doc Link PMC1876226 Disease Relevance 0.26 Pain Relevance 0.04
Only C8orf53, MAL2, LOC286052, SQLE and KIAA0196 were upregulated in proportion to copy number gain or amplification of the 8q23.3-q24.21 region in the ERBB2-amplified tumors.
Positive_regulation (upregulated) of C8orf53 associated with cancer
3) Confidence 0.02 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.81 Pain Relevance 0

General Comments

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