INT208287

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 0.33
Pain Relevance 4.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Msn) nucleolus (Msn) plasma membrane (Msn)
cytoskeleton (Msn) nucleus (Msn) protein binding, bridging (Msn)
Anatomy Link Frequency
interneurons 3
spike 1
dopaminergic neurons 1
Msn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pyramidal cell 672 100.00 Very High Very High Very High
substance P 96 100.00 Very High Very High Very High
Dopamine 462 99.84 Very High Very High Very High
interneuron 6 98.20 Very High Very High Very High
GABAergic 36 95.88 Very High Very High Very High
projection neuron 190 95.64 Very High Very High Very High
Enkephalin 128 95.40 Very High Very High Very High
Action potential 86 90.64 High High
cerebral cortex 12 81.20 Quite High
Nucleus accumbens 600 75.68 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 33 96.44 Very High Very High Very High
Adhesions 1 81.00 Quite High
Apoptosis 1 69.88 Quite High
Pulmonary Fibrosis 3 45.20 Quite Low
Wound Healing 1 43.60 Quite Low
Asthma 5 39.68 Quite Low
Targeted Disruption 4 23.92 Low Low
Shock 1 13.12 Low Low
Cancer 13 5.00 Very Low Very Low Very Low
Decapitation 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, because little is known about MSN to interneuron projections, we concentrate our further discussion on the possible functional aspects of interactions between MSN.
MSN Binding (interactions) of in interneuron associated with pyramidal cell and interneuron
1) Confidence 0.41 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.61
Intrastriatal communication: interactions between MSN?
MSN Binding (interactions) of associated with pyramidal cell
2) Confidence 0.41 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.33
Recent insights into the role of an important class of inhibitory striatal interneurons, i.e., the fast-spiking GABAergic interneurons that are driven by excitatory cortical inputs and have a much more powerful inhibitory influence on MSN than recurrent collaterals of MSN themselves, have again questioned the significance of MSN–MSN interactions (Tepper et al. 2004).
MSN Binding (interactions) of in interneurons associated with pyramidal cell and gabaergic
3) Confidence 0.30 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.67
Recent insights into the role of an important class of inhibitory striatal interneurons, i.e., the fast-spiking GABAergic interneurons that are driven by excitatory cortical inputs and have a much more powerful inhibitory influence on MSN than recurrent collaterals of MSN themselves, have again questioned the significance of MSN–MSN interactions (Tepper et al. 2004).
MSN Binding (interactions) of in interneurons associated with pyramidal cell and gabaergic
4) Confidence 0.30 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.67
Moesin, a significant attachment protein, binds to the cell surface HSPG, syndecan-2 [34].
Moesin Binding (binds) of
5) Confidence 0.26 Published 2007 Journal Respir Res Section Body Doc Link PMC1876226 Disease Relevance 0.15 Pain Relevance 0
To determine whether these alterations in MSN excitability seen after reserpine treatment could be generalized to another widely accepted model of Parkinson disease, dopaminergic neurons were unilaterally lesioned with 6-OHDA.
MSN Binding (excitability) of in dopaminergic neurons associated with parkinson's disease
6) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0.10 Pain Relevance 0.28
The average minimal depolarizing current amplitude required to elicit spike discharge (rheobase) was significantly lower for MSN in dopamine-depleted animals (62.5±6.2 pA, n?
MSN Binding (lower) of in spike associated with dopamine
7) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.23
This is not only important for the MSN somatic excitability, but also relevant for their dendritic responsiveness to excitatory inputs.
MSN Binding (excitability) of
8) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.14
The current to threshold or rheobase was significantly lower for MSN in 6-OHDA lesioned animals (76±8.71 pA, n?
MSN Binding (lower) of
9) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0.08 Pain Relevance 0.13
M bicuculline, is completely different for each response: GABAA receptor blockade in D1-SP+ MSN (n?
MSN Binding (bicuculline) of associated with substance p
10) Confidence 0.07 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2893005 Disease Relevance 0 Pain Relevance 0.77
The present experimental work shows that suprathreshold corticostriatal responses are an electrophysiological footprint that serves to recognize whether a recorded MSN belongs to the direct or indirect pathway with high probability.
MSN Binding (recognize) of
11) Confidence 0.07 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2893005 Disease Relevance 0 Pain Relevance 0.49

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