INT208291

Context Info Confidence 0.44 First Reported 2007 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 9 Disease Relevance 5.42 Pain Relevance 3.36

mitochondrion (Pten) aging (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Anatomy Link Frequency muscle 2 Pten (Rattus norvegicus)

Pain Link Frequency Relevance Heat Paracetamol 480 99.16 cytokine 8 5.00 fibrosis 5 5.00 Inflammation 3 5.00 anesthesia 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Aging 304 99.98 Cancer 13 99.96 Hyperglycemia 32 99.90 Obesity 16 89.04 Frailty 40 88.08 Apoptosis 81 87.60 Muscle Disease 8 71.20 Body Weight 32 5.00 Death 16 5.00 Hypoxia 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Akt hyper-phosphorylation is associated with a loss of PTEN protein

Negative_regulation (loss) of PTEN protein

1) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.07 Pain Relevance 0.46

This increase in PTEN protein appeared to parallel decreases in the amount of Akt-Thr308 phosphorylation which support the notion that a loss of PTEN protein with aging may contribute to the hyper-phosphorylation of Akt, and that acetaminophen intervention may function in reducing Akt phosphorylation by increasing PTEN levels.

Negative_regulation (loss) of PTEN protein associated with paracetamol and aging

2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.48 Pain Relevance 0.39

Why aging decreases PTEN protein levels is not clear.

Negative_regulation (decreases) of PTEN protein associated with aging

3) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.56 Pain Relevance 0.45

Our data also show that pPTEN levels were decreased with aging and that acetaminophen treatment restored pPTEN comparable to that observed in 6- and 27-month rats (Figure 6).

Negative_regulation (decreased) of pPTEN associated with paracetamol and aging

4) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.84 Pain Relevance 0.41

Therefore, aging-associated hyperglycemia and decreases in pPTEN level may result in decreased PTEN protein levels, which could act to increase the phosphorylation of Akt at Thr308 in aging muscle.

Negative_regulation (decreased) of PTEN protein in muscle associated with hyperglycemia and aging

5) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.89 Pain Relevance 0.38

The data of the present study show that a loss of PTEN protein in aging may contribute to the increased phosphorylation of Akt, and that acetaminophen intervention can restore both PTEN and pPTEN levels.

Negative_regulation (loss) of PTEN protein associated with paracetamol and aging

6) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.78 Pain Relevance 0.38

Therefore, aging-associated hyperglycemia and decreases in pPTEN level may result in decreased PTEN protein levels, which could act to increase the phosphorylation of Akt at Thr308 in aging muscle.

Negative_regulation (decreases) of pPTEN in muscle associated with hyperglycemia and aging

7) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.88 Pain Relevance 0.43

It is thought that high glucose levels can result in decreased PTEN expression and decreases in PTEN phosphatase activity [14].

Negative_regulation (decreases) of PTEN

8) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.62 Pain Relevance 0.47

Drosophila protein J-1/Parkinson protein 7 (DJ-1/PARK7), a negative regulator of PTEN tumor suppressor and a potential prognostic marker for cancer, was increased by >30-fold at 24 hours and the tumor suppressor-related protein, hyaluronate binding protein-1 (HABP-1), was increased >15 fold (Fig. 4D and Table 1) while transgelin (TAGLN2), was the most significantly down-regulated protein at >14-fold (Fig. 4D and Table 2).

Negative_regulation (regulator) of PTEN associated with cancer

9) Confidence 0.19 Published 2007 Journal Respir Res Section Body Doc Link PMC1876226 Disease Relevance 0.29 Pain Relevance 0

General Comments

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