INT208335

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.11
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme regulator activity (Apoc3) lipid binding (Apoc3) transport (Apoc3)
extracellular space (Apoc3) extracellular region (Apoc3)
Anatomy Link Frequency
plasma 1
covering 1
Apoc3 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 9 98.24 Very High Very High Very High
Peripheral nervous system 5 62.04 Quite High
Multiple sclerosis 5 59.52 Quite High
Sciatic nerve 1 59.04 Quite High
Central nervous system 24 48.76 Quite Low
Neuritis 24 40.52 Quite Low
cytokine 13 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 285 99.78 Very High Very High Very High
Targeted Disruption 31 80.24 Quite High
Syndrome 19 60.16 Quite High
Multiple Sclerosis 6 59.52 Quite High
Autoimmune Disease 7 42.88 Quite Low
Experimental Autoimmune Neuritis 24 40.52 Quite Low
Disease 22 35.40 Quite Low
INFLAMMATION 13 5.00 Very Low Very Low Very Low
Immunization 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The next question is whether EM associated with apoE3, which is treated with ?
apoE3 Spec (whether) Binding (associated) of
1) Confidence 0.01 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.32 Pain Relevance 0.04
We also found that the dimerization of apoE3 by disulfide bonds causes the apoE-isoform dependence of the apoE binding affinity to lipids.
apoE3 Binding (dimerization) of associated with addiction
2) Confidence 0.01 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.66 Pain Relevance 0.05
Here we show that apoE3-HDL induces a strong cholesterol release, while apoE4-HDL induces a very weak release, and that this isoform-specific effect of apoE associated with lipid particle (HDL or EM) is due to the finding that (1) apoE4 has a higher affinity to lipid particles and thus a greater number of apoE4 molecules bind to lipid particles than apoE3, and (2) with increasing number of apoE molecules covering the surface of lipid particle, both apoE3 and apoE4 inhibit the lipid-particle-mediated cholesterol release.
apoE3 Binding (bind) of in covering associated with disorder of lipid metabolism
3) Confidence 0.01 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.83 Pain Relevance 0
Because of domain interaction, apoE4 bind preferentially to very low density lipoproteins, which are more rapidly removed from plasma than other lipoproteins such as HDL, to which apoE3 and apoE2 binds preferentially [164–166].
apoE3 Binding (binds) of in plasma associated with disorder of lipid metabolism
4) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.30 Pain Relevance 0.09

General Comments

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