INT208337

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.22
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Apoc4) extracellular region (Apoc4)
Anatomy Link Frequency
macrophage 2
embryonic stem cells 2
Apoc4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 8 97.00 Very High Very High Very High
Inflammation 26 89.44 High High
anesthesia 1 50.00 Quite Low
cytokine 26 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Intracerebroventricular 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 36 96.64 Very High Very High Very High
Targeted Disruption 6 95.88 Very High Very High Very High
Cardiovascular Disease 7 93.52 High High
Cancer 2 92.16 High High
Disorder Of Lipid Metabolism 95 91.92 High High
Necrosis 2 91.60 High High
Stress 7 76.80 Quite High
Disease 12 5.00 Very Low Very Low Very Low
Atherosclerosis 4 5.00 Very Low Very Low Very Low
Atherosclerotic Plaque 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The murine monocyte–macrophage cell line (RAW 264.7) stably transfected to produce equal amounts of human apoE3 or apoE4 was used.
Positive_regulation (transfected) of Gene_expression (produce) of apoE4 in macrophage
1) Confidence 0.03 Published 2007 Journal Biochemical and Biophysical Research Communications Section Abstract Doc Link PMC2096715 Disease Relevance 0.96 Pain Relevance 0.21
Mice expressing human apoE4 in place of mouse apoE were generated by the gene-targeting technique taking advantage of homologous recombination in embryonic stem cells (knock-in) as previously described [34].
Positive_regulation (generated) of Gene_expression (expressing) of apoE4 in embryonic stem cells associated with targeted disruption
2) Confidence 0.01 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.26 Pain Relevance 0

General Comments

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