INT208344

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 9.60
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
adipocytes 6
macrophages 3
hepatocytes 3
stromal cells 2
neurons 2
Apoe (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 644 99.88 Very High Very High Very High
agonist 28 80.48 Quite High
withdrawal 70 75.52 Quite High
Central nervous system 70 71.08 Quite High
Inflammation 26 55.52 Quite High
addiction 21 42.80 Quite Low
chemokine 1 35.60 Quite Low
cytokine 27 25.28 Quite Low
corticosteroid 28 5.00 Very Low Very Low Very Low
Neuritis 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 685 100.00 Very High Very High Very High
Targeted Disruption 47 99.68 Very High Very High Very High
Aging 28 99.40 Very High Very High Very High
Obesity 168 98.88 Very High Very High Very High
Disease 434 92.36 High High
Necrosis 15 89.68 High High
Cancer 15 89.32 High High
Atherosclerosis 84 89.00 High High
Cognitive Disorder 58 85.76 High High
Apoptosis 15 84.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
g/ml, respectively (Table 1), the apoE-isoform-specific cholesterol release was observed (Fig. 4) as was the case for apoE-HDL (Fig. 1), that is, apoE3-EM and apoE3-HDL induced cholesterol release from neurons, whereas apoE4-EM and apoE4-HDL induced little release.
Positive_regulation (induced) of Localization (release) of apoE in neurons associated with disorder of lipid metabolism
1) Confidence 0.48 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.30 Pain Relevance 0
Interestingly, the apoE-EM complex at certain apoE concentrations and apoE/EM particle ratios induces cholesterol release in an apoE-isoform-specific manner; apoE-EM3 induces cholesterol release, but apoE4-EM does not (Fig. 4), as observed in the cases of apoE3-HDL and apoE4-HDL (Fig. 1).
Positive_regulation (induces) of Localization (release) of apoE associated with disorder of lipid metabolism
2) Confidence 0.48 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.93 Pain Relevance 0
ApoE-isoform-specific lipid release mediated by apoE3- and apoE4-containing HDL
Positive_regulation (mediated) of Localization (release) of ApoE-isoform associated with disorder of lipid metabolism
3) Confidence 0.48 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.99 Pain Relevance 0
ApoE-dose-dependent inhibition of EM-mediated lipid release
Positive_regulation (mediated) of Localization (release) of ApoE-dose-dependent
4) Confidence 0.48 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.11 Pain Relevance 0
The ratio of ratio of PC per apoE at apoE concentrations of 0.1,1,10, and 30 ?
Positive_regulation (at) of Localization (ratio) of apoE
5) Confidence 0.48 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.11 Pain Relevance 0
Interestingly, the apoE-EM complex at certain apoE concentrations and apoE/EM particle ratios induces cholesterol release in an apoE-isoform-specific manner; apoE-EM3 induces cholesterol release, but apoE4-EM does not (Fig. 4), as observed in the cases of apoE3-HDL and apoE4-HDL (Fig. 1).
Positive_regulation (induces) of Localization (release) of apoE-isoform associated with disorder of lipid metabolism
6) Confidence 0.48 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.92 Pain Relevance 0
Moreover, as we previously reported [10], apoE4-HDL contains number of apoE molecules per particle twofold that of apoE3; however, apoE4-HDL induced a very-weak cholesterol release, whereas apoE3-HDL induced a strong cholesterol release (Figs. 1A and 1B).
Positive_regulation (induced) of Localization (release) of apoE associated with disorder of lipid metabolism
7) Confidence 0.48 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 1.27 Pain Relevance 0.04
This increase in nitrite production reflects an increase in the innate immune response of the APOE ?
Positive_regulation (increase) of Localization (response) of APOE
8) Confidence 0.44 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.51 Pain Relevance 0.03
Since previous studies have reported successful induction of ApoE secretion from other cell types, we decided to screen some candidates for ApoE inducing activity.
Positive_regulation (induction) of Localization (secretion) of ApoE
9) Confidence 0.22 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.33 Pain Relevance 0.11
Cig 30 transiently induced ApoE secretion by day 10 of culture but these levels were absent at subsequent time points.
Positive_regulation (induced) of Localization (secretion) of ApoE
10) Confidence 0.22 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.18 Pain Relevance 0.15
To confirm that Dex was solely responsible for the induction of ApoE secretion, we tested whether the two additional components of AIM induced ApoE expression.
Positive_regulation (induction) of Localization (secretion) of ApoE associated with dexamethasone
11) Confidence 0.22 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0 Pain Relevance 0.26
Pharmaceutical induction of ApoE secretion has been demonstrated in macrophages, hepatocytes, adipocytes and other cell types by a variety of agents.
Positive_regulation (induction) of Localization (secretion) of ApoE in adipocytes associated with obesity
12) Confidence 0.22 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.43 Pain Relevance 0.06
In macrophages, secretion of ApoE was induced by treatment with TGF?
Positive_regulation (induced) of Localization (secretion) of ApoE in macrophages
13) Confidence 0.22 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.41 Pain Relevance 0.15
When stimulated by Dex only, there was a linear increase in the rate of ApoE secretion from hMSCs.
Positive_regulation (increase) of Localization (secretion) of ApoE associated with dexamethasone
14) Confidence 0.22 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.33 Pain Relevance 0.26
Indomethacin and Dex also induced ApoE secretion, but we also observed high levels of unwanted adipogenesis (data not shown).
Positive_regulation (induced) of Localization (secretion) of ApoE associated with dexamethasone
15) Confidence 0.22 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.31 Pain Relevance 0.27
To examine the kinetics, longevity, and donor-dependency of the inducible ApoE secretion, a series of time course experiments were performed with hMSCs from eight donors.
Positive_regulation (inducible) of Localization (secretion) of ApoE associated with aging
16) Confidence 0.22 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.10 Pain Relevance 0.26
In the case of the Dex conditions, normalized ApoE levels dropped slightly, suggesting expansion of some cells with limited or no potential for ApoE secretion (Figure 6).
Neg (no) Positive_regulation (potential) of Localization (secretion) of ApoE associated with dexamethasone
17) Confidence 0.16 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0 Pain Relevance 0.17
In two studies employing rat hepatocytes, ApoE secretion was stimulated using dexamathasone, insulin, or a combination of both [26,27].
Positive_regulation (stimulated) of Localization (secretion) of ApoE in hepatocytes
18) Confidence 0.16 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.42 Pain Relevance 0.11
However, there was an exponential increase in the rate of ApoE secretion when treated with AIM and this was accompanied by differentiation into adipocytes.
Positive_regulation (increase) of Localization (secretion) of ApoE in adipocytes associated with obesity
19) Confidence 0.15 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.35 Pain Relevance 0.26
Pharmaceutical induction of ApoE secretion by multipotent mesenchymal stromal cells (MSCs)

Background

Positive_regulation (induction) of Localization (secretion) of ApoE in stromal cells
20) Confidence 0.15 Published 2008 Journal BMC Biotechnol Section Title Doc Link PMC2596794 Disease Relevance 0.75 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox