INT208346

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.78
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Apoc4) extracellular region (Apoc4)
Anatomy Link Frequency
plasma 1
covering 1
Apoc4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 75 98.24 Very High Very High Very High
Inflammatory response 19 93.32 High High
Peripheral nervous system 9 68.00 Quite High
Sciatic nerve 1 65.00 Quite High
Central nervous system 13 49.40 Quite Low
Multiple sclerosis 5 46.72 Quite Low
Neuritis 24 46.48 Quite Low
cytokine 68 36.96 Quite Low
ischemia 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 179 99.64 Very High Very High Very High
INFLAMMATION 98 98.24 Very High Very High Very High
Disorder Of Lipid Metabolism 104 97.70 Very High Very High Very High
Cardiovascular Disease 18 95.48 Very High Very High Very High
Stress 40 88.08 High High
Targeted Disruption 58 86.20 High High
Atherosclerosis 8 65.68 Quite High
Atherosclerotic Plaque 4 55.44 Quite High
Syndrome 34 50.00 Quite Low
Adhesions 5 47.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although apoE4 is strongly linked to both diseases, the molecular basis of these associations remains uncertain.
apoE4 Binding (linked) of associated with disease
1) Confidence 0.03 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 0.87 Pain Relevance 0.04
However, further clarification of the molecular mechanisms, the complexity of apoE4–HO-1 interactions, as well as the impact of apoE genotype on inflammation using in vivo animal models and human trials is needed.



apoE4 Binding (interactions) of associated with inflammation
2) Confidence 0.03 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 0.89 Pain Relevance 0.20
Here we show that apoE3-HDL induces a strong cholesterol release, while apoE4-HDL induces a very weak release, and that this isoform-specific effect of apoE associated with lipid particle (HDL or EM) is due to the finding that (1) apoE4 has a higher affinity to lipid particles and thus a greater number of apoE4 molecules bind to lipid particles than apoE3, and (2) with increasing number of apoE molecules covering the surface of lipid particle, both apoE3 and apoE4 inhibit the lipid-particle-mediated cholesterol release.
apoE4 Binding (bind) of in covering associated with disorder of lipid metabolism
3) Confidence 0.01 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.83 Pain Relevance 0
Because of domain interaction, apoE4 bind preferentially to very low density lipoproteins, which are more rapidly removed from plasma than other lipoproteins such as HDL, to which apoE3 and apoE2 binds preferentially [164–166].
apoE4 Binding (bind) of in plasma associated with disorder of lipid metabolism
4) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.18 Pain Relevance 0.07
Furthermore, while initial genotype data from a late-onset AD group and a control cohort failed to demonstrate any association between BACE1 and AD, following stratification for ApoE status it was concluded that a combination of a specific BACE1 allele (within BACE1 codon V262) and ApoE4 may increase AD risk over that attributed to ApoE4 alone [86].
ApoE4 Binding (combination) of associated with disease
5) Confidence 0.01 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.01 Pain Relevance 0

General Comments

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