INT20835

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Context Info
Confidence 0.43
First Reported 1990
Last Reported 2006
Negated 1
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 0.56
Pain Relevance 8.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
striatum 2
NS20Y 2
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 87 100.00 Very High Very High Very High
Morphine 69 100.00 Very High Very High Very High
narcan 23 100.00 Very High Very High Very High
opioid receptor 16 100.00 Very High Very High Very High
Analgesic 5 99.26 Very High Very High Very High
tolerance 12 97.32 Very High Very High Very High
Pain 3 96.84 Very High Very High Very High
agonist 3 92.00 High High
antinociception 7 87.76 High High
withdrawal 4 87.20 High High
Disease Link Frequency Relevance Heat
Repression 14 100.00 Very High Very High Very High
Pain 3 96.84 Very High Very High Very High
Targeted Disruption 4 75.28 Quite High
Opiate Addiction 3 75.00 Quite High
Disease 4 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, naloxone and naltrexone stimulated adenylyl cyclase activity in striatum homogenates only after morphine pretreatment, by reversing the inhibitory effects of basal MOR activity.
Negative_regulation (reversing) of Negative_regulation (effects) of MOR in striatum associated with narcan and morphine
1) Confidence 0.43 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14600246 Disease Relevance 0.14 Pain Relevance 1.23
Results of radioligand binding and transfected receptor studies indicate that mu-receptor down-regulation and phosphorylation may be critical to the expression of morphine tolerance.
Negative_regulation (down) of Negative_regulation (regulation) of mu-receptor associated with tolerance and morphine
2) Confidence 0.42 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9582426 Disease Relevance 0 Pain Relevance 0.79
Functional deletion of the beta-arrestin 2 gene in mice resulted in remarkable potentiation and prolongation of the analgesic effect of morphine, suggesting that muOR desensitization was impaired.
Negative_regulation (impaired) of Negative_regulation (desensitization) of muOR associated with analgesic and morphine
3) Confidence 0.41 Published 1999 Journal Science Section Abstract Doc Link 10617462 Disease Relevance 0.08 Pain Relevance 0.85
mu-Opioid receptor down-regulation and cAMP-dependent protein kinase phosphorylation in a mouse model of chronic morphine tolerance.
Negative_regulation (down) of Negative_regulation (regulation) of mu-Opioid receptor associated with narcan, tolerance, opioid receptor and morphine
4) Confidence 0.37 Published 1998 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9582426 Disease Relevance 0 Pain Relevance 1.14
mu-Opioid receptor down-regulation and cAMP-dependent protein kinase phosphorylation in a mouse model of chronic morphine tolerance.
Negative_regulation (regulation) of Negative_regulation (down) of mu-Opioid receptor associated with narcan, tolerance, opioid receptor and morphine
5) Confidence 0.37 Published 1998 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9582426 Disease Relevance 0 Pain Relevance 1.14
In addition, we also investigated whether the transcriptional repression activity of the putative Sp-binding site in the MOR promoter can be relieved in the NS20Y cells after mithramycin A treatment.
Negative_regulation (relieved) of Negative_regulation (repression) of MOR promoter in NS20Y associated with repression and mu opioid receptor
6) Confidence 0.36 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.10 Pain Relevance 0.12
However, whether abrogating muOR desensitization affects the reinforcing and psychomotor properties of morphine has remained unexplored.
Spec (whether) Negative_regulation (abrogating) of Spec (whether) Negative_regulation (desensitization) of muOR associated with morphine
7) Confidence 0.33 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614085 Disease Relevance 0.25 Pain Relevance 1.05
In the ex vitro washout experiments, CCAM-mediated mu receptor binding inhibition could not be reversed even after allowing for 8 hr hr dissociation, whereas the CCAM inhibition of delta and kappa receptor binding was time-dependently reversed.
Neg (not) Negative_regulation (reversed) of Negative_regulation (inhibition) of mu receptor
8) Confidence 0.11 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8858971 Disease Relevance 0 Pain Relevance 0.28
AZINE pretreatment 24 hr earlier partially blocked MOR disruption of MB (40% responded; significantly different from MOR alone).
Negative_regulation (blocked) of Negative_regulation (disruption) of MOR associated with morphine
9) Confidence 0.02 Published 1990 Journal Physiol. Behav. Section Abstract Doc Link 2158113 Disease Relevance 0 Pain Relevance 1.66
The GAP activity of RGS-R4 and RGS-Rz proteins restricts the amplitude of opioid analgesia, and the efficient deactivation of GalphazGTP subunits by RGS-Rz proteins prevents mu receptor desensitization.
Negative_regulation (prevents) of Negative_regulation (desensitization) of mu receptor
10) Confidence 0.00 Published 2005 Journal Psychopharmacology (Berl.) Section Body Doc Link 15830230 Disease Relevance 0 Pain Relevance 0
Reduction of GRK2 and GRK3 levels by antisense, but not sense DNA treatment blocks ORL1 and mu receptor desensitization.
Negative_regulation (blocks) of Negative_regulation (desensitization) of mu receptor
11) Confidence 0.00 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130708 Disease Relevance 0 Pain Relevance 0.69

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