INT208354

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Context Info
Confidence 0.13
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 8.37
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
central nervous system 4
neurons 1
Apoe (Mus musculus)
Hdl1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 33 100.00 Very High Very High Very High
Central nervous system 88 95.12 Very High Very High Very High
Neuritis 48 74.20 Quite High
Multiple sclerosis 10 10.56 Low Low
cytokine 26 5.00 Very Low Very Low Very Low
Inflammation 24 5.00 Very Low Very Low Very Low
anesthesia 11 5.00 Very Low Very Low Very Low
Immobilon 11 5.00 Very Low Very Low Very Low
Peripheral nervous system 10 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 1035 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 48 74.20 Quite High
Syndrome 38 71.80 Quite High
Disease 69 59.84 Quite High
Multiple Sclerosis 12 10.56 Low Low
Targeted Disruption 82 8.64 Low Low
Neurodegenerative Disease 4 7.84 Low Low
INFLAMMATION 26 5.00 Very Low Very Low Very Low
Autoimmune Disease 14 5.00 Very Low Very Low Very Low
Immunization 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The last issue to be addressed is the cause of the apoE-isoform dependence of the preferential association of apoE with HDL and EM particles.
apoE Binding (association) of HDL associated with addiction and disorder of lipid metabolism
1) Confidence 0.13 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.60 Pain Relevance 0.05
To elucidate the mechanism underlying the apoE-isoform-specific effect on cholesterol release mediated by apoE-HDL, we used a complex consisting of lipid emulsion (EM) and recombinant human apoE3 or apoE4, because one cannot modulate the number of apoE molecules associated with HDL, but one can modulate apoE number associated with EM.
apoE Binding (associated) of HDL associated with disorder of lipid metabolism
2) Confidence 0.13 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 1.04 Pain Relevance 0.04
However, there is only one isoform of apoE in rodents, which resembles human apoE3 in terms of lipoprotein binding and metabolism, preferably associating with high density lipoprotein (HDL), the clearance of which is mediated principally by hepatic low density lipoprotein receptors (LDLRs) [3, 4].
apoE Binding (associating) of HDL associated with disorder of lipid metabolism
3) Confidence 0.10 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.47 Pain Relevance 0.15
The last issue to be addressed is the cause of the apoE-isoform dependence of the preferential association of apoE with HDL and EM particles.
apoE-isoform Binding (association) of HDL associated with addiction and disorder of lipid metabolism
4) Confidence 0.10 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.61 Pain Relevance 0.05
As a mechanism underlying this apoE-isoform specificity, we showed a novel action of apoE, that is, although apoE is a lipid acceptor, when apoE is associated with lipid particles such as HDL and EM, apoE inhibits lipid-particle-mediated cholesterol release in an apoE-dose-dependent manner.
apoE Binding (associated) of HDL associated with disorder of lipid metabolism
5) Confidence 0.10 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.62 Pain Relevance 0.03
As a mechanism underlying this apoE-isoform specificity, we showed a novel action of apoE, that is, although apoE is a lipid acceptor, when apoE is associated with lipid particles such as HDL and EM, apoE inhibits lipid-particle-mediated cholesterol release in an apoE-dose-dependent manner.
apoE Binding (associated) of HDL associated with disorder of lipid metabolism
6) Confidence 0.10 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.62 Pain Relevance 0.03
As a mechanism underlying this apoE-isoform specificity, we showed a novel action of apoE, that is, although apoE is a lipid acceptor, when apoE is associated with lipid particles such as HDL and EM, apoE inhibits lipid-particle-mediated cholesterol release in an apoE-dose-dependent manner.
apoE Binding (associated) of HDL associated with disorder of lipid metabolism
7) Confidence 0.10 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.62 Pain Relevance 0.03
Since the majority of apolipoprotein E (apoE) existing in the cerebrospinal fluid is associated with high-density lipoprotein (HDL), one should focus on the role of the apoE-HDL complex rather than on that of free apoE in cholesterol metabolism in the central nervous system.
apoE Binding (associated) of high-density lipoprotein in central nervous system associated with central nervous system and disorder of lipid metabolism
8) Confidence 0.09 Published 2007 Journal Mol Neurodegener Section Abstract Doc Link PMC1876452 Disease Relevance 0.61 Pain Relevance 0.05
Since the majority of apolipoprotein E (apoE) existing in the cerebrospinal fluid is associated with high-density lipoprotein (HDL), one should focus on the role of the apoE-HDL complex rather than on that of free apoE in cholesterol metabolism in the central nervous system.
apolipoprotein E Binding (associated) of HDL in central nervous system associated with central nervous system and disorder of lipid metabolism
9) Confidence 0.09 Published 2007 Journal Mol Neurodegener Section Abstract Doc Link PMC1876452 Disease Relevance 0.61 Pain Relevance 0.05
Since the majority of apolipoprotein E (apoE) existing in the cerebrospinal fluid is associated with high-density lipoprotein (HDL), one should focus on the role of the apoE-HDL complex rather than on that of free apoE in cholesterol metabolism in the central nervous system.
apoE Binding (associated) of HDL in central nervous system associated with central nervous system and disorder of lipid metabolism
10) Confidence 0.09 Published 2007 Journal Mol Neurodegener Section Abstract Doc Link PMC1876452 Disease Relevance 0.61 Pain Relevance 0.05
Our recent finding that the apoE-isoform-specific ability to generate HDL is associated with an apoE-isoform-specific ratio of apoE molecules per HDL particle [10] led us to examine the effect of apoE3- and apoE4-containing HDLs or lipid emulsions (EMs) at different apoE ratios on cholesterol release from neurons.
apoE-isoform Binding (associated) of HDL in neurons associated with disorder of lipid metabolism
11) Confidence 0.09 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.89 Pain Relevance 0.04
Since the majority of apolipoprotein E (apoE) existing in the cerebrospinal fluid is associated with high-density lipoprotein (HDL), one should focus on the role of the apoE-HDL complex rather than on that of free apoE in cholesterol metabolism in the central nervous system.
apolipoprotein E Binding (associated) of high-density lipoprotein in central nervous system associated with central nervous system and disorder of lipid metabolism
12) Confidence 0.09 Published 2007 Journal Mol Neurodegener Section Abstract Doc Link PMC1876452 Disease Relevance 0.61 Pain Relevance 0.05
However, there is only one isoform of apoE in rodents, which resembles human apoE3 in terms of lipoprotein binding and metabolism, preferably associating with high density lipoprotein (HDL), the clearance of which is mediated principally by hepatic low density lipoprotein receptors (LDLRs) [3, 4].
apoE Binding (associating) of high density lipoprotein associated with disorder of lipid metabolism
13) Confidence 0.09 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.47 Pain Relevance 0.15

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