INT20840

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 4.35
Pain Relevance 6.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car3) cytoplasm (Car3)
Anatomy Link Frequency
hippocampus 3
dentate gyrus 2
hippocampal formation 1
subiculum 1
posterior 1
Car3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 103 100.00 Very High Very High Very High
opioid receptor 17 100.00 Very High Very High Very High
Pyramidal cell 12 100.00 Very High Very High Very High
fortral 2 100.00 Very High Very High Very High
cocaine 4 99.68 Very High Very High Very High
Opioid 10 99.52 Very High Very High Very High
Morphine 23 99.22 Very High Very High Very High
antagonist 11 99.04 Very High Very High Very High
narcan 3 99.04 Very High Very High Very High
nMDA receptor antagonist 7 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 37 99.60 Very High Very High Very High
Brain Injury 124 98.76 Very High Very High Very High
Hypoxia 22 97.36 Very High Very High Very High
Depression 3 94.68 High High
Injury 132 93.24 High High
Gliosis 4 90.56 High High
Cicatrix 1 80.44 Quite High
Neurodegenerative Disease 1 65.68 Quite High
Drug Induced Neurotoxicity 5 47.44 Quite Low
Autism 1 45.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rats which exhibited seizures of level 3 or higher showed, within three days, a marked loss of pyramidal cells (60% in CA1 and CA3) and an increase in the density of glial fibrillary acidic protein immunostaining, representing an apparent increase in the number and size of astrocytes in all layers of the hippocampal CA1 subfield.
Negative_regulation (loss) of CA3 in astrocytes associated with convulsion and pyramidal cell
1) Confidence 0.47 Published 1997 Journal Neuroscience Section Abstract Doc Link 9316033 Disease Relevance 0.36 Pain Relevance 0.05
Several regions within the kindled group display a decrease in TBPS binding, including the subiculum, posterior lateral thalamic nuclei, the lateral hippocampus CA1, and the lateral hippocampus CA3.
Negative_regulation (decrease) of CA3 in posterior associated with hippocampus
2) Confidence 0.45 Published 1993 Journal Metab Brain Dis Section Abstract Doc Link 8190042 Disease Relevance 0.08 Pain Relevance 0.33
Hypoxia-induced seizures were followed by a depressant phase, which was manifested most prominently by a prolonged (up to several minutes) reduction in the frequency and intensity of burst-firing in the CA3 region, hyperpolarization of CA1 neurons, and undershoot of [K+]o.
Negative_regulation (reduction) of CA3 in neurons associated with convulsion and hypoxia
3) Confidence 0.42 Published 1990 Journal J. Neurophysiol. Section Abstract Doc Link 2158521 Disease Relevance 1.11 Pain Relevance 0.14
In contrast to inhibitory effects in other limbic areas, morphine and the opioid peptides predominantly excited CA1 and CA3 pyramidal neurons in a naloxone-sensitive manner, as previously reported [36].
Negative_regulation (excited) of CA3 in pyramidal neurons associated with pyramidal cell, narcan, opioid and morphine
4) Confidence 0.36 Published 1980 Journal Regul. Pept. Section Abstract Doc Link 6265978 Disease Relevance 0 Pain Relevance 1.06
All rats in the hippocampal lesion group sustained extensive loss of neurons in areas CA1, CA2, CA3, and the dentate gyrus (DG) throughout the entire longitudinal axis of the hippocampal formation.
Negative_regulation (loss) of CA3 in hippocampal formation
5) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2674562 Disease Relevance 0 Pain Relevance 0.05
Prenatal morphine exposure increased the mu-opioid receptor density in the CA1 of ovariectomized (OVX) females and in the CA3 of OVX, estradiol benzoate-plus progesterone (EB+P)-treated females, but decreased it in CA3 of OVX females.
Negative_regulation (decreased) of CA3 associated with opioid receptor and morphine
6) Confidence 0.32 Published 2003 Journal Hippocampus Section Abstract Doc Link 12836915 Disease Relevance 0 Pain Relevance 0.79
In male rats, there was a decrease in mu-opioid receptor density in the CA1 and CA3 of gonadectomized (GNX), testosterone 17beta-proprionate (TP)-treated males relative to GNX males regardless of prenatal morphine exposure.
Negative_regulation (decrease) of CA3 associated with opioid receptor and morphine
7) Confidence 0.32 Published 2003 Journal Hippocampus Section Abstract Doc Link 12836915 Disease Relevance 0 Pain Relevance 1.12
The induction of LTP at lateral perforant path-CA3 synapses, which is blocked by the opioid receptor antagonist naloxone, is also blocked by the selective mu opioid receptor antagonist Cys(2)-Tyr(3)-Orn(5)-Pen(7)-amide (CTOP), but not the selective delta opioid receptor antagonist naltrindole (NTI).
Negative_regulation (blocked) of CA3 in lateral associated with antagonist, mu opioid receptor, narcan and opioid receptor
8) Confidence 0.31 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 11826036 Disease Relevance 0 Pain Relevance 0.64
Seven days after the last kindled seizure, delta binding was decreased by 11-17% throughout CA1, CA3, and the dentate gyrus.
Negative_regulation (decreased) of CA3 in dentate gyrus associated with convulsion
9) Confidence 0.30 Published 1987 Journal Brain Res. Section Abstract Doc Link 3038268 Disease Relevance 0.52 Pain Relevance 0.48
Repeated and acute cocaine administration decreased the Go alpha messenger RNA level in the CA3 region and increased it in the CA1 at various time points.
Negative_regulation (decreased) of CA3 associated with cocaine
10) Confidence 0.23 Published 1994 Journal Neuroscience Section Abstract Doc Link 7700512 Disease Relevance 0 Pain Relevance 0.63
Contrary to the reduced inhibition in CA1 pyramidal cells [15] and CA3 to CA1 pathway [16] of the hippocampus, dentate gyrus granule cells [15] and the entorhinal cortex to dentate gyrus pathway demonstrated enhanced inhibition 2-15 days after fluid percussion TBI in rats [16].
Negative_regulation (inhibition) of CA3 in dentate gyrus associated with pyramidal cell, hippocampus and brain injury
11) Confidence 0.21 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2893123 Disease Relevance 1.06 Pain Relevance 0.37
JO 1784 (3 mg/kg subcutaneously) successfully attenuated this loss of [3H] (+)-pentazocine binding sites in the hippocampus (CA1, CA3 and CA4 regions) and in the substantia innominata.
Negative_regulation (loss) of CA3 in hippocampus associated with fortral and hippocampus
12) Confidence 0.18 Published 1996 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8737963 Disease Relevance 0.07 Pain Relevance 0.37
Several regions within the kindled group display a decrease in TBPS binding, including the subiculum, posterior lateral thalamic nuclei, the lateral hippocampus CA1, and the lateral hippocampus CA3.
Negative_regulation (decrease) of CA3 in subiculum associated with hippocampus
13) Confidence 0.15 Published 1993 Journal Metab Brain Dis Section Abstract Doc Link 8190042 Disease Relevance 0.08 Pain Relevance 0.33
Such a reduction in the number of synapses in CA3 might explain the reduced pCREB and pERK expression that we have found in the hippocampus and the decreased step-down latency found in LMH pups.
Negative_regulation (reduction) of CA3 in hippocampus associated with hippocampus
14) Confidence 0.15 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2871377 Disease Relevance 0 Pain Relevance 0.09
Contrary to the reduced inhibition in CA1 pyramidal cells [15] and CA3 to CA1 pathway [16] of the hippocampus, dentate gyrus granule cells [15] and the entorhinal cortex to dentate gyrus pathway demonstrated enhanced inhibition 2-15 days after fluid percussion TBI in rats [16].
Negative_regulation (inhibition) of CA3 in hippocampus associated with pyramidal cell, hippocampus and brain injury
15) Confidence 0.07 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2893123 Disease Relevance 1.06 Pain Relevance 0.37

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox