INT208407

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.52
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (NGLY1)
Anatomy Link Frequency
bands 1
NGLY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 4 52.84 Quite High
cytokine 15 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Peripheral nervous system 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Scrapie 78 92.72 High High
Viral Meningitis 2 80.68 Quite High
Flavivirus Infection 7 78.12 Quite High
Infection 96 66.36 Quite High
Disease 21 52.76 Quite High
Dengue 15 50.00 Quite Low
Creutzfeldt Jakob Disease 23 5.00 Very Low Very Low Very Low
Prion Diseases 11 5.00 Very Low Very Low Very Low
Chronic Wasting Disease 8 5.00 Very Low Very Low Very Low
Sprains And Strains 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to verify that the detected bands originated from PrPSc, a control experiment was performed: After deglycosylation with PNGaseF, the PrP27–30 bands showed an electrophoretic shift towards a single band at about 20 kDa, the molecular weight to be expected for the unglycosylated PrP27–30 form of 263K hamster scrapie (Figure 1F, lanes S1d–S5d).
PNGase Binding (deglycosylation) of in bands associated with scrapie
1) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1876502 Disease Relevance 0.36 Pain Relevance 0
CRD4–7 did not bind sE deglycosylated with peptide:N-glycosidase F (PNGaseF) (Figure 2A, right-hand lane), in contrast to 3H5 that bound to both the native and the deglycosylated forms of the protein (Figure 2B), indicating that CRD4–7 binds specifically to N-linked glycans on sE.
PNGaseF Binding (bound) of
2) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.16 Pain Relevance 0.03

General Comments

This test has worked.

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