INT20845

Context Info Confidence 0.70 First Reported 1990 Last Reported 2001 Negated 2 Speculated 1 Reported most in Abstract Documents 7 Total Number 8 Disease Relevance 1.81 Pain Relevance 7.33

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Anatomy Link Frequency NG108-15 2 brain 2 Oprd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 21 100.00 Morphine 17 100.00 narcan 13 100.00 Enkephalin 3 100.00 Immobilon 2 100.00 Pain 9 99.96 Opioid 20 99.80 action potential duration 4 99.52 Potency 3 99.36 tolerance 16 98.92

Disease Link Frequency Relevance Heat Pain 9 99.96 Glioma 3 99.68 Neuroblastoma 2 99.50 Alcohol Addiction 6 98.52 Nociception 4 91.76 Ganglion Cysts 1 78.68 Bordatella Infection 2 63.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Additionally, it is suggested that chronic exposure to pain produces a constant elevation of opioid peptides leading to opioid receptor downregulation and consequently morphine tolerance.

Positive_regulation (leading) of Negative_regulation (downregulation) of opioid receptor associated with pain, tolerance, opioid receptor, opioid and morphine

1) Confidence 0.70 Published 1995 Journal Brain Res. Section Abstract Doc Link 8925291 Disease Relevance 0.38 Pain Relevance 1.32

Previous study has demonstrated that chronic treatment of [D-Ala2,D-Leu5] enkephalin (DADLE) induces profound down-regulation of delta opioid receptor in rat brain.

Positive_regulation (induces) of Negative_regulation (down-regulation) of delta opioid receptor in brain associated with opioid receptor and enkephalin

2) Confidence 0.50 Published 1998 Journal Chin J Physiol Section Abstract Doc Link 10099869 Disease Relevance 0 Pain Relevance 0.48

Delta opioid receptor down-regulation is independent of functional G protein yet is dependent on agonist efficacy.

Neg (independent) Positive_regulation (independent) of Negative_regulation (down-regulation) of Delta opioid receptor associated with agonist, enkephalin and opioid receptor

3) Confidence 0.24 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9808689 Disease Relevance 0.16 Pain Relevance 0.57

Chronic opioid treatment of neuroblastoma x glioma NG108-15 cells induces desensitization of the opioid receptor and this may involve a change in membrane protein phosphorylation.

Positive_regulation (induces) of Negative_regulation (desensitization) of opioid receptor in NG108-15 associated with neuroblastoma, opioid receptor, opioid and glioma

4) Confidence 0.07 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2158550 Disease Relevance 0.35 Pain Relevance 0.43

In summary, except the opioid receptor uncoupling and opioid receptor down-regulation, chronic morphine treatment may also activate pain facilitatory systems (NMDA receptor activation, NO production, and COX ac-tivation) during opioid tolerance development.

Spec (may) Positive_regulation (activate) of Neg (except) Negative_regulation (down-regulation) of opioid receptor associated with pain, nmda receptor, tolerance, opioid receptor, opioid and morphine

5) Confidence 0.07 Published 2000 Journal Acta Anaesthesiol. Sin. Section Abstract Doc Link 11125691 Disease Relevance 0.34 Pain Relevance 1.86

FHP subjects had greater ACTH and cortisol response to opioid receptor blockade induced by naloxone hydrochloride compared with FHN subjects.

Positive_regulation (induced) of Negative_regulation (blockade) of opioid receptor

6) Confidence 0.05 Published 2001 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 11505044 Disease Relevance 0.07 Pain Relevance 0

Selective blockade of excitatory opioid receptor functions by low (ca. pM) concentrations of naloxone, naltrexone, etorphine and other specific agents markedly increases the inhibitory potency of morphine or other bimodally acting agonists and attenuates development of tolerance/dependence.

Positive_regulation (increases) of Negative_regulation (blockade) of opioid receptor associated with addiction, tolerance, agonist, narcan, opioid receptor, morphine, potency and immobilon

7) Confidence 0.04 Published 1996 Journal Neurochem. Res. Section Abstract Doc Link 8947924 Disease Relevance 0.16 Pain Relevance 1.86

This study was designed to evaluate ACTH responses to opioid receptor blockade as a function of family history for alcohol dependence.

Positive_regulation (responses) of Negative_regulation (blockade) of opioid receptor associated with addiction, opioid receptor and alcohol

8) Confidence 0.01 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 9920063 Disease Relevance 0.35 Pain Relevance 0.82

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