INT20845

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1990
Last Reported 2001
Negated 2
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.81
Pain Relevance 7.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Anatomy Link Frequency
NG108-15 2
brain 2
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 21 100.00 Very High Very High Very High
Morphine 17 100.00 Very High Very High Very High
narcan 13 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
Immobilon 2 100.00 Very High Very High Very High
Pain 9 99.96 Very High Very High Very High
Opioid 20 99.80 Very High Very High Very High
action potential duration 4 99.52 Very High Very High Very High
Potency 3 99.36 Very High Very High Very High
tolerance 16 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 9 99.96 Very High Very High Very High
Glioma 3 99.68 Very High Very High Very High
Neuroblastoma 2 99.50 Very High Very High Very High
Alcohol Addiction 6 98.52 Very High Very High Very High
Nociception 4 91.76 High High
Ganglion Cysts 1 78.68 Quite High
Bordatella Infection 2 63.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, it is suggested that chronic exposure to pain produces a constant elevation of opioid peptides leading to opioid receptor downregulation and consequently morphine tolerance.
Positive_regulation (leading) of Negative_regulation (downregulation) of opioid receptor associated with pain, tolerance, opioid receptor, opioid and morphine
1) Confidence 0.70 Published 1995 Journal Brain Res. Section Abstract Doc Link 8925291 Disease Relevance 0.38 Pain Relevance 1.32
Previous study has demonstrated that chronic treatment of [D-Ala2,D-Leu5] enkephalin (DADLE) induces profound down-regulation of delta opioid receptor in rat brain.
Positive_regulation (induces) of Negative_regulation (down-regulation) of delta opioid receptor in brain associated with opioid receptor and enkephalin
2) Confidence 0.50 Published 1998 Journal Chin J Physiol Section Abstract Doc Link 10099869 Disease Relevance 0 Pain Relevance 0.48
Delta opioid receptor down-regulation is independent of functional G protein yet is dependent on agonist efficacy.
Neg (independent) Positive_regulation (independent) of Negative_regulation (down-regulation) of Delta opioid receptor associated with agonist, enkephalin and opioid receptor
3) Confidence 0.24 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9808689 Disease Relevance 0.16 Pain Relevance 0.57
Chronic opioid treatment of neuroblastoma x glioma NG108-15 cells induces desensitization of the opioid receptor and this may involve a change in membrane protein phosphorylation.
Positive_regulation (induces) of Negative_regulation (desensitization) of opioid receptor in NG108-15 associated with neuroblastoma, opioid receptor, opioid and glioma
4) Confidence 0.07 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2158550 Disease Relevance 0.35 Pain Relevance 0.43
In summary, except the opioid receptor uncoupling and opioid receptor down-regulation, chronic morphine treatment may also activate pain facilitatory systems (NMDA receptor activation, NO production, and COX ac-tivation) during opioid tolerance development.
Spec (may) Positive_regulation (activate) of Neg (except) Negative_regulation (down-regulation) of opioid receptor associated with pain, nmda receptor, tolerance, opioid receptor, opioid and morphine
5) Confidence 0.07 Published 2000 Journal Acta Anaesthesiol. Sin. Section Abstract Doc Link 11125691 Disease Relevance 0.34 Pain Relevance 1.86
FHP subjects had greater ACTH and cortisol response to opioid receptor blockade induced by naloxone hydrochloride compared with FHN subjects.
Positive_regulation (induced) of Negative_regulation (blockade) of opioid receptor
6) Confidence 0.05 Published 2001 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 11505044 Disease Relevance 0.07 Pain Relevance 0
Selective blockade of excitatory opioid receptor functions by low (ca. pM) concentrations of naloxone, naltrexone, etorphine and other specific agents markedly increases the inhibitory potency of morphine or other bimodally acting agonists and attenuates development of tolerance/dependence.
Positive_regulation (increases) of Negative_regulation (blockade) of opioid receptor associated with addiction, tolerance, agonist, narcan, opioid receptor, morphine, potency and immobilon
7) Confidence 0.04 Published 1996 Journal Neurochem. Res. Section Abstract Doc Link 8947924 Disease Relevance 0.16 Pain Relevance 1.86
This study was designed to evaluate ACTH responses to opioid receptor blockade as a function of family history for alcohol dependence.
Positive_regulation (responses) of Negative_regulation (blockade) of opioid receptor associated with addiction, opioid receptor and alcohol
8) Confidence 0.01 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 9920063 Disease Relevance 0.35 Pain Relevance 0.82

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox