INT208467

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 40.09
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL16) extracellular region (IL16) plasma membrane (IL16)
nucleus (IL16) intracellular (IL16) cytoplasm (IL16)
Anatomy Link Frequency
bowel 2
macrophages 1
cerebrospinal fluid 1
saliva 1
IL16 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 255 98.88 Very High Very High Very High
Crohn's disease 210 98.40 Very High Very High Very High
Multiple sclerosis 30 96.64 Very High Very High Very High
rheumatoid arthritis 30 95.52 Very High Very High Very High
COX2 3 94.84 High High
cytokine 64 85.00 Quite High
chemokine 10 80.04 Quite High
abdominal pain 31 5.00 Very Low Very Low Very Low
cva 30 5.00 Very Low Very Low Very Low
ischemia 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 454 100.00 Very High Very High Very High
Disease 2974 99.92 Very High Very High Very High
Recurrence 390 99.54 Very High Very High Very High
Neurologic Manifestations 270 99.32 Very High Very High Very High
Inflammatory Bowel Disease 300 99.28 Very High Very High Very High
Cv Unclassified Under Development 300 99.16 Very High Very High Very High
Eczema 30 98.92 Very High Very High Very High
INFLAMMATION 143 98.88 Very High Very High Very High
Rickettsiaceae Infection 120 98.64 Very High Very High Very High
Immune System Diseases 30 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is likely that increased levels of circulating IL-16 and nucleosomes in patients with WD are a hallmark of the disease and can permit doctors to discriminate between subjects with WD and healthy carriers.
Positive_regulation (increased) of IL-16 associated with disease
1) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.30 Pain Relevance 0
Indeed, subjects which were PCR positive for T. whipplei in their stool and saliva but who lacked clinical manifestations did not exhibit increased levels of IL-16 and nucleosomes.
Neg (not) Positive_regulation (increased) of IL-16 in saliva
2) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.30 Pain Relevance 0.08
Increased serum levels of IL-16 have been associated with atopic dermatitis in children, but are not correlated with severity of the disease [39].
Positive_regulation (Increased) of IL-16 associated with eczema and disease
3) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.49 Pain Relevance 0.09
In untreated patients with WD, circulating levels of IL-16 were significantly (p<0.001) increased as compared to asymptomatic subjects and control subjects (Fig 1A).
Positive_regulation (increased) of IL-16 associated with disease
4) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 0.76 Pain Relevance 0
The combination of increased levels of IL-16 and caspase 3 activity has been reported in cerebrospinal fluid from patients with multiple sclerosis and experimental autoimmune encephalomyelitis, and is correlated with disease activity [37], [38].
Positive_regulation (increased) of IL-16 in cerebrospinal fluid associated with multiple sclerosis and disease
5) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.63 Pain Relevance 0.10
Circulating IL-16 and nucleosomes in treated WD patients
Positive_regulation (Circulating) of IL-16 associated with disease
6) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 0.70 Pain Relevance 0
To determine if high levels of IL-16 and nucleosomes are related to active WD, we monitored circulating IL-16 and nucleosomes in 26 patients treated with antibiotics and in 8 patients with relapses despite antibiotic treatment.
Positive_regulation (levels) of IL-16 associated with disease and recurrence
7) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 0.78 Pain Relevance 0
Using a rather small number of patients with active WD, we found that the sensitivity and the specificity of measurements of circulating IL-16 and nucleosomes have a good value for the diagnosis of active WD.
Positive_regulation (measurements) of IL-16 associated with disease
8) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.14 Pain Relevance 0.03
Circulating IL-16 and nucleosomes were related in untreated patients with WD (y?
Positive_regulation (Circulating) of IL-16 associated with disease
9) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 0.91 Pain Relevance 0
To determine if high levels of IL-16 and nucleosomes are related to active WD, we monitored circulating IL-16 and nucleosomes in 26 patients treated with antibiotics and in 8 patients with relapses despite antibiotic treatment.
Positive_regulation (circulating) of IL-16 associated with disease and recurrence
10) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 0.84 Pain Relevance 0
As compared to the infective endocarditis due to C. burnetii, untreated patients with endocarditis due to T. whipplei exhibited significantly (p<0.01) higher levels of circulating IL-16 (Fig. 2C) and nucleosomes (Fig 2D).
Positive_regulation (circulating) of IL-16 associated with bacterial endocarditis and cv unclassified under development
11) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.47 Pain Relevance 0.13
While increased IL-16 has been reported in local lesions of chronic immune diseases, including allergen-induced bronchial asthma and rheumatoid arthritis [34] and in the mucosa of patients with inflammatory bowel disease, including ulcerative colitis and Crohn's disease [35], [36], the systemic role of IL-16 is a new finding.
Positive_regulation (increased) of IL-16 in bowel associated with asthma, inflammatory bowel disease, crohn's disease, inflammation, rheumatoid arthritis, disease and immune system diseases
12) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.77 Pain Relevance 0.17
Finally, high levels of circulating IL-16 and nucleosomes were related to the activity of WD because the successful antibiotic treatment decreased both markers in patients with WD.
Positive_regulation (levels) of IL-16 associated with disease
13) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.19 Pain Relevance 0
Increased circulating levels of IL-16 and nucleosomes were specific to WD.
Positive_regulation (Increased) of IL-16 associated with disease
14) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.41 Pain Relevance 0.07
The first patient exhibited low levels of IL-16 and nucleosomes during the total duration of his treatment; few months after the arrest of his treatment, he presented clinical symptoms of relapses, and both circulating IL-16 and nucleosomes were increased (Fig 3C).
Positive_regulation (increased) of IL-16 associated with recurrence
15) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.31 Pain Relevance 0
Indeed, circulating levels of IL-16 were not increased in patients with ulcerative colitis or Crohn's disease even though IL-16 is expressed in tissue lesions.
Neg (not) Positive_regulation (increased) of IL-16 associated with inflammatory bowel disease, crohn's disease and disease
16) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.55 Pain Relevance 0.19
In preliminary experiments, we have shown that circulating levels of IL-16 are increased in some patients with WD [16].
Positive_regulation (increased) of IL-16 associated with disease
17) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 0.95 Pain Relevance 0.12
Conversely, circulating IL-16 was increased in patients with WD (our results) and is produced by macrophages isolated from blood [16], but the expression of IL-16 is not increased in macrophages infiltrating intestinal lesions of one patient with WD [15], suggesting that IL-16 is associated with the systemic phase of WD.
Positive_regulation (increased) of IL-16 in macrophages associated with disease
18) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.59 Pain Relevance 0.18
The levels of circulating IL-16 and nucleosomes were transiently increased during the clinical relapses, and decreased when clinical symptoms disappeared after newly designed antibiotic therapy (Fig 3D).
Positive_regulation (increased) of IL-16 associated with recurrence
19) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.47 Pain Relevance 0.03
We also found that increased levels of IL-16 and nucleosomes were related to the activity of the disease.
Positive_regulation (increased) of IL-16 associated with disease
20) Confidence 0.45 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1876813 Disease Relevance 1.66 Pain Relevance 0.10

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