INT208476

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 7.23
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Pkd1) plasma membrane (Pkd1) nucleus (Pkd1)
cilium (Pkd1)
Anatomy Link Frequency
margin 1
gland 1
Pkd1 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 1 99.74 Very High Very High Very High
anesthesia 7 82.32 Quite High
ketamine 6 79.24 Quite High
Bioavailability 6 40.40 Quite Low
fibrosis 14 39.12 Quite Low
Potency 7 13.60 Low Low
imagery 45 5.00 Very Low Very Low Very Low
Mechanosensation 24 5.00 Very Low Very Low Very Low
Somatostatin 24 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 114 100.00 Very High Very High Very High
Infection 84 100.00 Very High Very High Very High
Polycystic Kidney Disease 384 99.36 Very High Very High Very High
Repression 36 96.36 Very High Very High Very High
Bartter Syndrome 6 92.08 High High
Cyst 217 90.92 High High
Autosomal Dominant Polycystic Kidney 117 89.16 High High
Congenital Anomalies 42 88.88 High High
Syndrome 39 88.64 High High
Disease 217 88.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas the housekeeping gyrase genes were no longer repressed, the expression of the guanine riboswitch operon was still reduced, consistent with PC1 binding the riboswitch operon and inhibiting gene expression.
PC1 Binding (binding) of
1) Confidence 0.39 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858708 Disease Relevance 0.28 Pain Relevance 0
Nevertheless, the restricted nature of growth inhibition likely indicates that PC1 inhibits bacterial growth through riboswitch binding and not via an alternative mechanism such as DNA incorporation (Figure 6).
PC1 Binding (binding) of
2) Confidence 0.30 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858708 Disease Relevance 0.38 Pain Relevance 0
The binding affinity of PC1 suggests that the guanine riboswitch can tolerate modifications on the ligand pyrimidine ring that are not strongly deleterious for complex formation (?
PC1 Binding (affinity) of
3) Confidence 0.29 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858708 Disease Relevance 0.13 Pain Relevance 0
It is not excluded that other riboswitch-controlled genes may participate in the PC1-dependent bacterial growth inhibition (e.g., guaB), or that PC1 may bind other cellular targets, which alone or in combination with the riboswitch-controlled gene repression, would repress bacterial growth.
PC1 Binding (bind) of associated with repression
4) Confidence 0.29 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858708 Disease Relevance 0.31 Pain Relevance 0
Mice mammary glands were treated 4 h after infection with PBS or PBS with 10, 50 and 100 µg/gland of PC1 and mice were sacrified 6 h later for mammary gland sampling and homogenization.
PC1 Binding (infection) of in gland associated with infection
5) Confidence 0.26 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858708 Disease Relevance 0.23 Pain Relevance 0.12
We also performed growth inhibition experiments using various concentrations of both PC1 and PC2 (Figure S2).
PC1 Binding (concentrations) of
6) Confidence 0.26 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858708 Disease Relevance 0.05 Pain Relevance 0
The deregulation of Ca2+ signaling in cystic cells is believed to be mediated by polycystin-2 in complex with polycystin-1.
polycystin-1 Binding (complex) of
7) Confidence 0.22 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.72 Pain Relevance 0
Cystogenesis in humans and mice occurs in trans-heterozygotes with PKD1 and PKD2 mutations [26, 27].
PKD1 Binding (heterozygotes) of
8) Confidence 0.22 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.74 Pain Relevance 0
Genetic interaction between murine genes encoding polycystin-1 and fibrocystin was shown, suggesting that polycystin-1 and fibrocystin function in the same molecular pathway to maintain tubular integrity [85].
polycystin-1 Binding (interaction) of
9) Confidence 0.22 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.62 Pain Relevance 0
Polycystin-1 appeared to form a complex with tuberin and regulate the activity of mTOR, an important regulator of protein synthesis and cellular differentiation [95].
Polycystin-1 Spec (appeared) Binding (complex) of
10) Confidence 0.22 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.50 Pain Relevance 0
(a) Polycystin-1 (PC-1) mediates cell-cell adhesion through homophilic interactions of its Ig-like domains.
Polycystin-1 Binding (interactions) of associated with adhesions
11) Confidence 0.22 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 1.07 Pain Relevance 0
It has been shown that polycystin-1 interacts with focal adhesion complex molecules including ?
polycystin-1 Binding (interacts) of associated with adhesions
12) Confidence 0.21 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.95 Pain Relevance 0
Polycystin-2 is a member of the calcium-permeable subfamily of transient receptor potential channels and forms a complex with polycystin-1 [17].
polycystin-1 Binding (complex) of associated with trp channel
13) Confidence 0.21 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 1.24 Pain Relevance 0.05
Conversely, in D. buzzatii, the Cactus by Line interaction was significant for PC1, which describes changes in the process of the ventral margin (Figure 1) and accounts for an important proportion (30%) of the explained morphological variance.


PC1 Binding (accounts) of in margin
14) Confidence 0.03 Published 2007 Journal BMC Evol Biol Section Body Doc Link PMC1878482 Disease Relevance 0 Pain Relevance 0

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