INT2085

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Context Info
Confidence 0.70
First Reported 1970
Last Reported 2010
Negated 32
Speculated 11
Reported most in Abstract
Documents 441
Total Number 455
Disease Relevance 60.15
Pain Relevance 191.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 82
blood 23
pituitary 18
MPOA 11
hypothalamus 9
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 1424 100.00 Very High Very High Very High
Clonidine 54 100.00 Very High Very High Very High
Locus ceruleus 50 100.00 Very High Very High Very High
cytokine 33 100.00 Very High Very High Very High
substance P 29 100.00 Very High Very High Very High
noradrenaline 11 100.00 Very High Very High Very High
halothane 2 100.00 Very High Very High Very High
Cannabinoid 2 100.00 Very High Very High Very High
antagonist 401 99.96 Very High Very High Very High
antinociception 49 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 193 100.00 Very High Very High Very High
Nociception 116 100.00 Very High Very High Very High
Diabetes Mellitus 29 100.00 Very High Very High Very High
Stress 787 99.98 Very High Very High Very High
Body Weight 158 99.96 Very High Very High Very High
Aids-related Complex 54 99.66 Very High Very High Very High
Galactorrhea 29 99.58 Very High Very High Very High
Hypotension 15 99.48 Very High Very High Very High
Aging 33 99.24 Very High Very High Very High
Hemorrhage 16 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that electrical stimulation of the LH engages an endogenous opiate system which is capable of producing prolonged analgesia.
Positive_regulation (stimulation) of LH associated with opiate and analgesia
1) Confidence 0.70 Published 1995 Journal Exp. Neurol. Section Abstract Doc Link 7556548 Disease Relevance 0.35 Pain Relevance 0.96
We found that naloxone increased serum LH and testosterone levels over essentially the same time course and produced dose-dependent increases in serum testosterone levels even though LH levels were maximally elevated at all doses.
Positive_regulation (increased) of LH associated with narcan
2) Confidence 0.70 Published 1989 Journal Endocrinology Section Abstract Doc Link 2666108 Disease Relevance 0 Pain Relevance 0.36
We found that naloxone increased serum LH and testosterone levels over essentially the same time course and produced dose-dependent increases in serum testosterone levels even though LH levels were maximally elevated at all doses.
Positive_regulation (elevated) of LH associated with narcan
3) Confidence 0.70 Published 1989 Journal Endocrinology Section Abstract Doc Link 2666108 Disease Relevance 0 Pain Relevance 0.43
Mean blood LH levels and the rate at which blood LH levels changed during individual pulses remained reduced, and a slight fall occurred in the extent of the increase in blood LH levels during single LH episodes.
Positive_regulation (increase) of LH in blood
4) Confidence 0.70 Published 1978 Journal Neuroendocrinology Section Abstract Doc Link 732952 Disease Relevance 0 Pain Relevance 0.36
In ovariectomized rats without oestradiol supplentation, nalmefene alone was able to increase basal LH levels, but unable to facilitate a spontaneous rise in LH amplitude indicative of an LH surge.
Neg (unable) Positive_regulation (increase) of LH
5) Confidence 0.70 Published 1988 Journal J. Endocrinol. Section Abstract Doc Link 3339293 Disease Relevance 0 Pain Relevance 0.17
In the present study, we investigated the role of opiates in the induction of LH and SIA under different conditions.
Spec (investigated) Positive_regulation (induction) of LH associated with opiate and analgesia
6) Confidence 0.70 Published 1997 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 9292116 Disease Relevance 0.27 Pain Relevance 1.12
When injected together with synthetic LH-releasing hormone (400 ng/kg), salmefamol (125 micrograms/kg) significantly increased the mean plasma concentrations of LH over 70 min compared with values in controls receiving LH-releasing hormone only.
Positive_regulation (increased) of LH in plasma
7) Confidence 0.70 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 2875653 Disease Relevance 0 Pain Relevance 0.35
Thirty minutes after acute (2 min.) exposure to ether, plasma LH levels were elevated compared to controls; morphine (MOR) treatment prior to stress prevented this response.
Positive_regulation (elevated) of LH in plasma associated with stress and morphine
8) Confidence 0.70 Published 1984 Journal Life Sci. Section Abstract Doc Link 6374352 Disease Relevance 0.33 Pain Relevance 0.39
Clonidine induced increases in serum LH were not altered by nicotine treatment and haloperidol treatment did not alter nicotine induced decreases in serum LH.
Positive_regulation (increases) of LH associated with nicotine and clonidine
9) Confidence 0.70 Published 1997 Journal Life Sci. Section Abstract Doc Link 9194685 Disease Relevance 0 Pain Relevance 0.66
Naltrexone (2 mg) administered at t = -15 min induced higher plasma LH levels at t = -6 min.
Positive_regulation (induced) of LH in plasma
10) Confidence 0.70 Published 1997 Journal Life Sci. Section Abstract Doc Link 9064478 Disease Relevance 0.23 Pain Relevance 0.53
After 45 min., LH levels were in the same range as baseline level in the diabetic group; but were still significantly elevated in the control rats.
Positive_regulation (elevated) of LH associated with diabetes mellitus
11) Confidence 0.70 Published 1987 Journal Life Sci. Section Abstract Doc Link 3600195 Disease Relevance 0.45 Pain Relevance 0.27
The opiate antagonist, naloxone, significantly increased both noradrenaline (NA) turnover and plasma LH levels.
Positive_regulation (increased) of LH in plasma associated with antagonist, noradrenaline, narcan and opiate
12) Confidence 0.69 Published 1989 Journal J. Neurol. Sci. Section Abstract Doc Link 2559164 Disease Relevance 0 Pain Relevance 1.29
In all groups, stimulation of VNAT elicited a significant increase in plasma LH concentration.
Positive_regulation (increase) of LH in plasma
13) Confidence 0.69 Published 1987 Journal Brain Res. Section Abstract Doc Link 3607492 Disease Relevance 0.31 Pain Relevance 0.54
In 32-week OVX rats, even the lower-dose naloxone did not induce an elevation in mean LH levels.
Positive_regulation (elevation) of LH associated with narcan
14) Confidence 0.69 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2118607 Disease Relevance 0.06 Pain Relevance 0.32
In 4-week OVX rats, a significant increase in the mean LH level was observed through the 90-min period of lower-dose naloxone treatment, without significant changes in the pulse frequency and amplitude.
Positive_regulation (increase) of LH associated with narcan
15) Confidence 0.69 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2118607 Disease Relevance 0.09 Pain Relevance 0.36
In 4-week OVX rats treated with the higher dose and in 16-week OVX rats treated with either the lower or the higher dose, a significant elevation in mean LH levels was observed only during the first 30 min of treatment, which was probably related to the first, large LH peak in the naloxone treatment period.
Positive_regulation (elevation) of LH associated with narcan
16) Confidence 0.69 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2118607 Disease Relevance 0.07 Pain Relevance 0.43
Naloxone increased LH levels up to a dose of 1 mg/kg, after which no further increases were found.
Positive_regulation (increased) of LH associated with narcan
17) Confidence 0.69 Published 1979 Journal Endocrinology Section Abstract Doc Link 374068 Disease Relevance 0 Pain Relevance 0.51
The exogenous opioid morphine blocked the increase in LH produced by naloxone in a dose-dependent fashion, suggesting that the specific receptor-blocking effects of the antagonist could account for its enhancement of serum LH levels.
Positive_regulation (increase) of LH associated with antagonist, narcan, opioid and morphine
18) Confidence 0.69 Published 1979 Journal Endocrinology Section Abstract Doc Link 374068 Disease Relevance 0 Pain Relevance 0.63
In chronically-pinealectomized rats, but not in sham-pinealectomized rats, naloxone injected 60 min after the end of the stress session evoked a significant increase in serum LH concentrations.
Positive_regulation (increase) of LH associated with stress and narcan
19) Confidence 0.69 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9535053 Disease Relevance 0.48 Pain Relevance 0.50
Naloxone causes rapid, dose-dependent increases in serum LH levels in the male, apparently by blocking the actions of an endogenously occurring opioid peptide which normally inhibits the release of LH.
Positive_regulation (increases) of LH associated with narcan and opioid
20) Confidence 0.69 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7005427 Disease Relevance 0 Pain Relevance 1.00

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