INT208511

Context Info Confidence 0.13 First Reported 2007 Last Reported 2011 Negated 0 Speculated 1 Reported most in Body Documents 24 Total Number 34 Disease Relevance 11.51 Pain Relevance 0.80

transport (Use1) vesicle-mediated transport (Use1) endoplasmic reticulum (Use1)

Anatomy Link Frequency lungs 3 macrophages 1 blood vessels 1 Th1 cells 1 neutrophils 1 Use1 (Mus musculus)

Pain Link Frequency Relevance Heat chemokine 100 100.00 Pain 40 99.16 Inflammation 160 90.88 cytokine 120 83.96 abdominal pain 12 39.20 alcohol 10 11.88 cva 14 5.00 Piles 4 5.00 nud 4 5.00 spastic colon 2 5.00

Disease Link Frequency Relevance Heat Alzheimer's Dementia 50 100.00 Mycobacterial Infection 1450 99.96 Shock 40 99.50 Infection 1102 99.20 Pain 40 99.16 INFLAMMATION 160 90.88 Injury 12 88.80 Granuloma 50 75.80 Stress 10 71.44 Diabetes Mellitus 24 58.84

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These data suggest that induction of neutrophil-associated chemokines such as CXCL9 and CXCL10 on D12–D15 may be key to accumulation of activated Th1 cells in the lung on D21.

Positive_regulation (induction) of D12 in Th1 cells associated with chemokine and infection

1) Confidence 0.13 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.10 Pain Relevance 0.05

Also, our experimental data showing the accumulation of Gr1+ neutrophils and monocytes on D12 in the M.tuberculosis-infected lung validates our gene expression profiles.

Positive_regulation (accumulation) of D12 in lung associated with mycobacterial infection

2) Confidence 0.11 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.35 Pain Relevance 0

Our data show that both S100A8 and S100A9 are induced in the D12-M.tuberculosis-infected lungs (Table 7).

Positive_regulation (induced) of D12-M in lungs associated with mycobacterial infection

3) Confidence 0.08 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.53 Pain Relevance 0.13

For example, 204 mRNAs were similarly induced or repressed on D12 and D15, 272 mRNAs on D15 and D21 and 195 mRNAs on D21 and D12.

Positive_regulation (induced) of D12

4) Confidence 0.08 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.87 Pain Relevance 0.03

For example, 204 mRNAs were similarly induced or repressed on D12 and D15, 272 mRNAs on D15 and D21 and 195 mRNAs on D21 and D12.

Positive_regulation (induced) of D12

5) Confidence 0.08 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.93 Pain Relevance 0.03

Histologically, we observed an increased accumulation of Gr1+ cells around blood vessels on D12 and D15, while Gr1+ cells were observed in the lung interstitium by D21 (Figure 5c).

Positive_regulation (accumulation) of D12 in blood vessels associated with infection

6) Confidence 0.08 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.84 Pain Relevance 0.06

However, a group of mRNAs included those encoding the host heat shock proteins (Table 1) were induced at D12.

Positive_regulation (induced) of D12 associated with shock

7) Confidence 0.08 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.89 Pain Relevance 0.05

Strikingly, we found significant induction of transcripts encoding Serum amyloid protein 3 (SAA3) in the D12 M.tuberculosis-infected lungs (Table 7).

Positive_regulation (induction) of D12 in lungs associated with mycobacterial infection and alzheimer's dementia

8) Confidence 0.08 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.87 Pain Relevance 0.08

Interestingly, the transcripts for C-type lectin MDL-1 (CLEC5A), which is mainly expressed by neutrophils and macrophages, were induced at D12 with considerable increase in their levels at D21 [27].

Positive_regulation (increase) of D12 in macrophages associated with infection

9) Confidence 0.07 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.35 Pain Relevance 0.08

It is suggested that this might be due to the fact that they have a more positive attitude towards care-seeking [20,19] and they have different beliefs concerning health and illness. [46] However we did not find evidence for ethnic differences in mismatch between referral and diagnosis, general practitioners can cause differences in referrals between immigrant and Dutch patients, when communication with immigrant patients is less effective than in consultations with Dutch patients, there is more misunderstanding and also more non-compliance. [47] These explanations could also contribute to the interpretation of the finding that the increased use of health care services predominantly can be ascribed to the first-generation immigrants.

Positive_regulation (increased) of use of health care

10) Confidence 0.03 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2538538 Disease Relevance 0.17 Pain Relevance 0

Interestingly, the transcripts for C-type lectin MDL-1 (CLEC5A), which is mainly expressed by neutrophils and macrophages, were induced at D12 with considerable increase in their levels at D21 [27].

Positive_regulation (increase) of D12 in neutrophils associated with infection

11) Confidence 0.03 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.35 Pain Relevance 0.08

This increased use can be predominantly ascribed to the first-generation immigrants; second-generation immigrants do not appear to have an increased use of health care services.

Positive_regulation (increased) of use of health care

12) Confidence 0.02 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2538538 Disease Relevance 0.05 Pain Relevance 0

To advance the field, we recommend that investigators: (1) use theoretically informed interventions to increase research use, (2) measure research use longitudinally using theoretically informed and psychometrically sound measures of research use, as well as, measuring patient outcomes relevant to the intervention, and (3) use more robust and methodologically sound study designs to evaluate interventions.

Positive_regulation (increase) of research use

13) Confidence 0.02 Published 2007 Journal Implement Sci Section Abstract Doc Link PMC1878499 Disease Relevance 0 Pain Relevance 0

There has been considerable interest recently in developing and evaluating interventions to increase research use by clinicians.

Positive_regulation (increase) of research use

14) Confidence 0.02 Published 2007 Journal Implement Sci Section Abstract Doc Link PMC1878499 Disease Relevance 0 Pain Relevance 0

If investigators aim to establish a link between using research and improved patient outcomes they must first identify those interventions that are effective at increasing research use.

Positive_regulation (increasing) of research use

15) Confidence 0.02 Published 2007 Journal Implement Sci Section Abstract Doc Link PMC1878499 Disease Relevance 0 Pain Relevance 0

The current state of the science provides little guidance to individuals charged with implementing strategies to increase research use in nursing practice.

Positive_regulation (increase) of research use

16) Confidence 0.02 Published 2007 Journal Implement Sci Section Body Doc Link PMC1878499 Disease Relevance 0.05 Pain Relevance 0.05

The purpose of this article is to report findings from a systematic review of interventions aimed at increasing research use in nursing.

Positive_regulation (increasing) of research use

17) Confidence 0.02 Published 2007 Journal Implement Sci Section Abstract Doc Link PMC1878499 Disease Relevance 0 Pain Relevance 0

If investigators aim to establish a link between using research and improved patient outcomes they must first establish those interventions that are effective at increasing research use.

Positive_regulation (increasing) of research use

18) Confidence 0.02 Published 2007 Journal Implement Sci Section Body Doc Link PMC1878499 Disease Relevance 0 Pain Relevance 0

One study was found in which formation of multidisciplinary committees was reported to be effective at increasing nurses' research use related to oncology pain [24].

Positive_regulation (increasing) of research use associated with pain

19) Confidence 0.02 Published 2007 Journal Implement Sci Section Body Doc Link PMC1878499 Disease Relevance 0.10 Pain Relevance 0.10

Randomized controlled trials and controlled before- and after-studies were included if they included nurses, if the intervention was explicitly aimed at increasing research use or evidence-based practice, and if there was an explicit outcome to research use.

Positive_regulation (increasing) of research use

20) Confidence 0.02 Published 2007 Journal Implement Sci Section Abstract Doc Link PMC1878499 Disease Relevance 0 Pain Relevance 0

General Comments

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