INT208515

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.51
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Gpi1) carbohydrate metabolic process (Gpi1) cytoplasm (Gpi1)
cytosol (Gpi1) extracellular space (Gpi1) extracellular region (Gpi1)
Anatomy Link Frequency
granulocytes 2
NK cells 2
Gpi1 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 1 85.28 High High
cva 14 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
headache 8 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Paroxysmal Nocturnal Hemoglobinuria 194 99.84 Very High Very High Very High
Atherosclerosis 6 99.48 Very High Very High Very High
Stress 3 99.02 Very High Very High Very High
Apoptosis 4 98.28 Very High Very High Very High
Coronary Artery Disease 53 97.68 Very High Very High Very High
Hemolysis 58 89.68 High High
Cv General 3 Under Development 3 85.28 High High
Disease 32 85.04 High High
Cardiovascular Disease 1 82.88 Quite High
Syndrome 2 63.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For the remainder of genes in this pathway, both alleles would need to be mutated in the same cell to affect GPI production.
Regulation (affect) of Gene_expression (production) of GPI
1) Confidence 0.11 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789686 Disease Relevance 0.38 Pain Relevance 0
Another potential mechanism that has been proposed is that lack of GPI molecules on PNH cells can render them resistant to apoptosis.33,34 However, other investigators have failed to observe this difference in apoptosis rates between GPI deficient and normal granulocytes.35
Regulation (lack) of Gene_expression (molecules) of GPI in granulocytes associated with paroxysmal nocturnal hemoglobinuria and apoptosis
2) Confidence 0.08 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789686 Disease Relevance 1.11 Pain Relevance 0
It is worthy to stress out that the Bruunsgaard's data illustrates the changes in NK cells compartment in an early atherosclerosis and not in fully symptomatic CHD, which can explain discrepancy between this report and our study.
Regulation (changes) of Gene_expression (compartment) of NK in NK cells associated with stress, coronary artery disease and atherosclerosis
3) Confidence 0.05 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1878503 Disease Relevance 1.02 Pain Relevance 0.09

General Comments

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