INT208522

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.20
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SCGB1A1) extracellular region (SCGB1A1) cytoplasm (SCGB1A1)
Anatomy Link Frequency
urine 2
monocyte 1
uterus 1
neutrophil 1
SCGB1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 8 96.24 Very High Very High Very High
metalloproteinase 2 94.16 High High
chemokine 8 89.84 High High
Inflammation 68 84.80 Quite High
member 8 2 66.16 Quite High
cytokine 14 40.16 Quite Low
Inflammatory mediators 27 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fabry Disease 42 97.24 Very High Very High Very High
Proteinuria 88 96.90 Very High Very High Very High
Disease 87 93.56 High High
Renal Disease 112 91.12 High High
INFLAMMATION 102 84.80 Quite High
Prostate Cancer 90 84.36 Quite High
Systemic Lupus Erythematosus 18 83.72 Quite High
Benign Prostatic Hypertrophy 230 83.60 Quite High
Autoimmune Disease 10 82.72 Quite High
Chronic Renal Failure 22 73.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ERT alone will not reduce overt proteinuria in Fabry disease (Wilcox et al 2004; Banikazemi et al 2007; Germain et al 2007; Schiffmann 2007; Schiffmann et al 2007; Warnock 2007), but maintenance of urine protein excretion at ?
Gene_expression (excretion) of urine protein in urine associated with proteinuria and fabry disease
1) Confidence 0.65 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727881 Disease Relevance 1.01 Pain Relevance 0
Renal and nonrenal flares were identified and uMCP-1, urine protein to urine creatinine ratio (uP:C), and plasma levels of complement components C3 and C4 were measured.
Gene_expression (measured) of urine protein in urine
2) Confidence 0.65 Published 2010 Journal Theor Biol Med Model Section Body Doc Link PMC2877652 Disease Relevance 1.10 Pain Relevance 0.08
Additional highly expressed, androgen-regulated genes included KLK3 (PSA), MSMB (beta-microseminoprotein), ACPP (prostatic acid phosphatase) and SCGB1A1 (uteroglobin).


Gene_expression (expressed) of uteroglobin
3) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 0.38 Pain Relevance 0.25
Additional highly expressed, androgen-regulated genes included KLK3 (PSA), MSMB (beta-microseminoprotein), ACPP (prostatic acid phosphatase) and SCGB1A1 (uteroglobin).


Gene_expression (expressed) of SCGB1A1
4) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 0.38 Pain Relevance 0.25
An immunomodulatory role has also been suggested for uteroglobin, an unusually small globular protein that is produced in maximal quantities during the secretory phase and is a potent inhibitor of neutrophil and monocyte chemotaxis in vitro [34,35].
Gene_expression (produced) of uteroglobin in neutrophil
5) Confidence 0.32 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0.11 Pain Relevance 0
Prolactin also stimulates progesterone-induced uteroglobin expression in the rabbit uterus [44].
Gene_expression (expression) of uteroglobin in uterus
6) Confidence 0.25 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0.11 Pain Relevance 0
An immunomodulatory role has also been suggested for uteroglobin, an unusually small globular protein that is produced in maximal quantities during the secretory phase and is a potent inhibitor of neutrophil and monocyte chemotaxis in vitro [34,35].
Gene_expression (produced) of uteroglobin in monocyte
7) Confidence 0.11 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0.11 Pain Relevance 0

General Comments

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