INT208536

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 4.83
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Anatomy Link Frequency
neuronal 4
band 2
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 43 97.64 Very High Very High Very High
Dopamine 3 96.40 Very High Very High Very High
Kinase C 14 96.36 Very High Very High Very High
dopaminergic neurodegeneration 3 95.88 Very High Very High Very High
Substantia nigra 12 93.60 High High
ischemia 7 87.84 High High
agonist 10 86.80 High High
Eae 4 67.80 Quite High
cINOD 29 64.08 Quite High
Serotonin 8 60.80 Quite High
Disease Link Frequency Relevance Heat
Death 117 100.00 Very High Very High Very High
Parkinson's Disease 120 99.98 Very High Very High Very High
Toxicity 36 99.98 Very High Very High Very High
Targeted Disruption 125 99.10 Very High Very High Very High
Disease 314 98.96 Very High Very High Very High
Apoptosis 35 97.32 Very High Very High Very High
Cv Unclassified Under Development 7 87.84 High High
Injury 3 85.52 High High
Neurodegenerative Disease 84 73.72 Quite High
Cognitive Disorder 85 73.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine which of these two scenarios might account for enhanced levels of phospho-Ser-9-GSK3?
Spec (might) Positive_regulation (account) of Positive_regulation (enhanced) of GSK3
1) Confidence 0.30 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 0.07 Pain Relevance 0.03
Inactivation of GSK-3 increases ?
Positive_regulation (increases) of Positive_regulation (increases) of GSK-3
2) Confidence 0.28 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0 Pain Relevance 0.06
Quantification of protein band intensities demonstrated significant increases in p-Akt(Ser473) levels in the cortex and hippocampus of lithium-treated 3-month-old Tg mice as compared to the age-matched Tg controls (Fig. 7 L), indicating that an Akt-mediated inactivation of GSK-3?
Positive_regulation (mediated) of Positive_regulation (inactivation) of GSK-3 in band associated with targeted disruption and hippocampus
3) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004858 Disease Relevance 0.61 Pain Relevance 0.19
Although GSK3 hyperactivation can mediate the acute effects of A?
Positive_regulation (mediate) of Positive_regulation (hyperactivation) of GSK3
4) Confidence 0.21 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 0.54 Pain Relevance 0
Taken together, our results suggest a dual role for active GSK-3?
Positive_regulation (role) of Positive_regulation (role) of GSK-3
5) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.53 Pain Relevance 0.06
in vivo in MPTP-induced dopaminergic neuronal cell death, we first examined the activation of GSK-3?
Spec (examined) Positive_regulation (induced) of Spec (examined) Positive_regulation (activation) of GSK-3 in neuronal associated with parkinson's disease and death
6) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.97 Pain Relevance 0.05
Finally, two other PD mimetics, 6-hydroxydopamine (6-OHDA) and rotenone, induce neuronal death through the activation of GSK-3?
Positive_regulation (induce) of Positive_regulation (activation) of GSK-3 in neuronal associated with disease and death
7) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 1.26 Pain Relevance 0.14
toxicity induced the activation of GSK-3?
Positive_regulation (induced) of Positive_regulation (activation) of GSK-3 associated with toxicity
8) Confidence 0.07 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.85 Pain Relevance 0.59

General Comments

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