INT208537

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.15
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 15 100.00 Very High Very High Very High
tolerance 20 88.88 High High
Eae 24 83.72 Quite High
Pyramidal cell 9 62.36 Quite High
antidepressant 3 58.96 Quite High
Dopamine 7 54.04 Quite High
depression 7 25.52 Quite Low
Hippocampus 11 5.00 Very Low Very Low Very Low
long-term potentiation 6 5.00 Very Low Very Low Very Low
monoamine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 33 97.92 Very High Very High Very High
Stress 21 96.40 Very High Very High Very High
Sprains And Strains 37 93.80 High High
Targeted Disruption 65 92.48 High High
Spinocerebellar Ataxia Type 2 47 86.80 High High
Apoptosis 3 85.60 High High
Aggression 13 60.80 Quite High
Cognitive Disorder 17 54.32 Quite High
Congenital Anomalies 3 50.00 Quite Low
Cancer 2 49.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To check the status of basal levels of CORT in GSK-3?
Regulation (status) of Gene_expression (levels) of GSK-3 associated with corticosteroid
1) Confidence 0.36 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.56 Pain Relevance 0.42
We speculated that hepatic deletion of GSK-3?
Regulation (speculated) of Gene_expression (deletion) of GSK-3
2) Confidence 0.35 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 1.03 Pain Relevance 0.04
Lithium has diverse molecular targets (including GSK3?)
Regulation (targets) of Gene_expression (including) of GSK3
3) Confidence 0.33 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 0.56 Pain Relevance 0.03
The evidence in support of our argument is: (i) BMAL1 protein has a longer half-life in GSK3??
Regulation (half) of Gene_expression (life) of GSK3
4) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0 Pain Relevance 0.03

General Comments

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