INT208538

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 4.49
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Anatomy Link Frequency
striatum 2
brain 2
cortex 2
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 165 100.00 Very High Very High Very High
Dopamine 8 98.52 Very High Very High Very High
Neurotransmitter 3 98.00 Very High Very High Very High
Pyramidal cell 17 57.52 Quite High
Kinase C 31 55.36 Quite High
Hippocampus 37 49.76 Quite Low
antidepressant 15 27.92 Quite Low
depression 25 5.40 Low Low
cerebral cortex 18 5.00 Very Low Very Low Very Low
corticosteroid 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 575 99.36 Very High Very High Very High
Sprains And Strains 14 97.80 Very High Very High Very High
Neurodegenerative Disease 30 96.20 Very High Very High Very High
Schizophrenia 20 94.76 High High
Disease 126 93.68 High High
Adhesions 2 93.68 High High
Affective Disorder 9 93.00 High High
Attention Deficit Hyperactivity Disorder 65 92.28 High High
Shock 12 91.20 High High
Manic Depressive Disorder 92 90.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, in the present study we focused solely on the cortical changes of Akt and GSK3 phosphorylation.
Regulation (changes) of Phosphorylation (phosphorylation) of GSK3
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.41 Pain Relevance 0.04
Some reports have shown that lithium affects both Akt and GSK3 phosphorylation in the striatum of WT animals [36].
Regulation (affects) of Phosphorylation (phosphorylation) of GSK3 in striatum
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.37 Pain Relevance 0.04
On the other hand, GSK activity reflected the ratio of phosphor-Ser9 GSK3?
Regulation (reflected) of Phosphorylation (phosphor) of GSK3
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.64 Pain Relevance 0
Effects of lithium on Akt and GSK3 phosphorylation may vary depending upon the brain region or the mouse strain.
Regulation (Effects) of Phosphorylation (phosphorylation) of GSK3 in brain associated with sprains and strains
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.42 Pain Relevance 0.04
Additionally, our results showing that LiCl (200 mg/kg i.p.) did not affect locomotor activity in WT mice (Figure 2c) may support the results of Akt and GSK3 phosphorylation in WT cortex.
Regulation (results) of Phosphorylation (phosphorylation) of GSK3 in cortex associated with eae
5) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.25 Pain Relevance 0.08
Dysregulation of GSK-3-substrate-mediated phosphorylation and associated signaling pathways have been implicated in the pathogenesis of psychiatric and neurodegenerative diseases, such as schizophrenia, Alzheimer's disease, bipolar mood disorder and ADHD [34-38].
Regulation (Dysregulation) of Phosphorylation (phosphorylation) of GSK-3-substrate-mediated associated with affective disorder, attention deficit hyperactivity disorder, disease, neurodegenerative disease and schizophrenia
6) Confidence 0.36 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 1.01 Pain Relevance 0.05
As an example, in a Drosophila melanogaster model, tau phosphorylation via its GSK-3 homologue Shaggy has been described to facilitate its aggregation to filamentous structures [21].
Regulation (facilitate) of Phosphorylation (phosphorylation) of GSK-3 associated with eae
7) Confidence 0.30 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915753 Disease Relevance 0.49 Pain Relevance 0.05
We therefore examined the effects of lithium treatment on the phosphorylation of Ser-9 of GSK3?
Spec (examined) Regulation (effects) of Phosphorylation (phosphorylation) of GSK3
8) Confidence 0.29 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 0 Pain Relevance 0
The effects of lithium on phosphorylated Akt and GSK3?
Regulation (effects) of Phosphorylation (phosphorylated) of GSK3
9) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.91 Pain Relevance 0.08

General Comments

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